生物谷報(bào)道：1月12日,，《英國醫(yī)學(xué)雜志》（BMJ）刊登報(bào)告，警告無糖香口珠內(nèi)含的甜味劑山梨糖醇（Sorbitol,，或E420）可能引致體重大幅下降,、腹痛及腹瀉。
據(jù)《英國醫(yī)學(xué)期刊》刊登的報(bào)告稱,，一塊無糖香口膠含1.25克山梨糖醇,，每天吃至少4塊或8粒無糖香口珠，便可能引致輕微腸胃問題,，出現(xiàn)腹脹及腸胃抽筋,。
報(bào)告參考一名21歲女病人及一名46歲男病人的病例，前者每天吃15塊無糖香口膠,，吸收約18至20克山梨糖醇,；后者則每天吃20塊無糖香口膠及最多200克糖果，吸收約30克山梨糖醇,。前者持續(xù)8個(gè)月出現(xiàn)腹痛及腹瀉,，51.8公斤的體重下跌11公斤，至體重過輕,；后者則持續(xù)1年受腹痛,、腹脹、胃氣脹及嚴(yán)重腹瀉折磨,，體重下跌22公斤,。
據(jù)介紹，醫(yī)學(xué)界早于20多年前已證實(shí)山梨糖醇難被人體吸收,，或會(huì)引起上述不良副作用,，美國食品及藥物管理局（FDA）現(xiàn)時(shí)將標(biāo)準(zhǔn)訂在每天50克,，即約50塊無糖香口膠或約100粒無糖香口珠。但發(fā)出報(bào)告的醫(yī)生表示,，每天吸收20克以上便可能引致腹瀉及體重下降,，并警告大眾不要借無糖香口膠減肥,。 （來源：信息時(shí)報(bào)）
生物谷推薦原始出處：
BMJ 2008;336:96-97 (12 January), doi:10.1136/bmj.39280.657350.BE
Practice
Lesson of the Week
Severe weight loss caused by chewing gum
Juergen Bauditz, consultant1, Kristina Norman, nutrition scientist1, Henrik Biering, junior doctor1, Herbert Lochs, head of department1, Matthias Pirlich, consultant1
1 Department of Gastroenterology, Hepatology, and Endocrinology, Charité Universitätsmedizin, 10117 Berlin, Germany
Correspondence to: J Bauditz [email protected]
Sorbitol intake should be considered in patients with bowel problems, chronic diarrhoea, and weight loss
About 10-20% of adults and adolescents are estimated to have symptoms related to functional bowel disorders, resulting in high healthcare costs.1 We report two cases of chronic diarrhoea and substantial weight loss in which extensive investigations had been performed previously. However, final diagnosis was only established after precise evaluation of eating habits, which showed habitual ingestion of sorbitol, a widely used sweetener in food products which has laxative properties.
Case reports
Case 1
A 21 year old woman had experienced diarrhoea and diffuse abdominal pain for eight months. She had four to 12 bowel movements with watery stools daily. She was initially suspected to have infectious colitis. However, as clinical investigation suggested no clear diagnosis and diarrhoea persisted, she was transferred to our department for further evaluation. At that time she had lost 11 kg and weighed 40.8 kg (body mass index 16.6). Laboratory analysis showed hypoalbuminaemia (albumin 30.7, normal range 33-50 g/l; total . . . [Full text of this article]
