最新研究顯示,，某些環(huán)境毒素會破壞女孩的荷爾蒙分泌,，從而影響女孩正常的成長發(fā)育,。這些毒素在環(huán)境中自然存在，例如鐮孢屬菌類會生成一種名叫玉米赤霉烯酮的真菌雌激素,。這種雌激素的性質(zhì)與女性體內(nèi)分泌的生殖雌激素相近,，同時在結(jié)構(gòu)上，與動物養(yǎng)殖中使用的生長激素相似,。2月份在線發(fā)表于愛思唯爾期刊《兒科學(xué)雜志》（Journal of Pediatrics）一篇文章報道，某些真菌雌激素可能是女孩性發(fā)育提前的直接原因,。
意大利比薩大學(xué)的Francesco Massart博士和同事對意大利托斯卡納區(qū)西北部的17名青春期提前（中樞性性早熟）的女孩進(jìn)行了調(diào)查研究,，以期發(fā)現(xiàn)該地區(qū)中樞性性早熟多發(fā)的原因。研究人員檢測了女孩體內(nèi)真菌雌激素的水平,，以確認(rèn)該毒素是否是女孩性早熟的原因,。
17名受測女孩中有6人被檢測出玉米赤霉烯酮偏高。Massart博士說：“這項研究具有偶然性因素,，但可以說明,，玉米赤霉烯酮可能導(dǎo)致接觸真菌雌激素的女孩青春期提前。由于托斯卡納區(qū)西北部還存在除草劑,、農(nóng)藥等環(huán)境毒素源,，所以玉米赤霉烯酮不能作為該地區(qū)女孩性早熟多發(fā)的解釋。”
文章作者同時指出,，由于玉米赤霉烯酮在化學(xué)上與動物養(yǎng)殖業(yè)中使用的一些生長激素有相似之處,，有理由懷疑它會導(dǎo)致兒童性早熟。盡管研究人員還不能確定托斯卡納區(qū)西北部中樞性性早熟多發(fā)的確切原因,，但該研究表明有必要進(jìn)一步研究環(huán)境污染物對兒童健康的不良影響,。（科學(xué)網(wǎng) 荔濤/編譯）
生物谷推薦原始出處：
（Journal of Pediatrics）,，DOI: 10.1016/j.peds.2007.10.020，F(xiàn)rancesco Massart, Giulio Soldani
High Growth Rate of Girls with Precocious Puberty Exposed to Estrogenic Mycotoxins
Francesco Massart MD, PhD, , , Valentina Meucci VD, PhD†, Giuseppe Saggese MD and Giulio Soldani MD†
†Department of Veterinary Clinics (V.M., G. Soldani), University of Pisa, Pisa, Italy
Department of Pediatrics (F.M., G. Saggese), University of Pisa, Pisa, Italy
Received 2 March 2007; revised 7 September 2007; accepted 19 October 2007. Available online 20 February 2008.
Objective
To test the hypothesis that human puberty timing can be advanced by environmental estrogen exposure.
Study design
We analyzed serum mycoestrogen contamination via high-performance liquid chromatography (HPLC) in 32 girls affected by central precocious puberty (CPP) and in 31 healthy female control subjects. All 32 patients received triptorelin (TR) for more than 12 months after diagnosis.
Results
Increased serum levels of zearalenone (ZEA; 933.7 ± 200.3 pg/mL; 95% CI, 723.5-1143.9) and of its congener α-zearalenol (106.5 ± 1.9 pg/mL; 95% CI, 104.5-108.5) contaminated 6 girls with CPP, who were from a bounded Tuscany area. At diagnosis, ZEA levels correlated with patient height (r = 0.906, P < .05) and weight (r = 0.887, P < .05), but not with bone age. In patients who were mycotoxin-positive, height (F = 4.192; P < .01), weight (F = 3.915; P < .01), and height velocity (F = 2.777, P < .05) were higher than patients who were mycotoxin-negative during 12-months TR treatment. Height correlated with weight both in patients who were mycotoxin-positive (r = 0.986, P < .001) and in patients who were mycotoxin-negative (r = 0.994, P < .001). Body mass index, bone age, and gonadal secretion was not different in patient groups before and during TR treatment (P > .05).
Conclusions
Mycoestrogenic zearalenone is suspected to be a triggering factor for CPP development in girls. Because of its chemical resemblance to some anabolic agents used in animal breeding, ZEA may also represent a growth promoter in exposed patients.
