一個國際研究小組日前發(fā)現了一些與潰瘍性結腸炎發(fā)病風險相關的遺傳標記,，這將有助于研發(fā)出有效藥物。
據《自然—遺傳學》雜志網絡版1月4日報道,，潰瘍性結腸炎是最常見的一種慢性炎癥性腸病,，而且通常具有家族性。研究人員推測,，遺傳因素可能發(fā)揮了某種作用,。來自美國匹茲堡大學醫(yī)學院等機構的研究人員對1052名潰瘍性結腸炎患者和2571名正常人的DNA（脫氧核糖核酸）樣本進行了全基因組掃描后發(fā)現，有2個遺傳標記與潰瘍性結腸炎的發(fā)病存在非常顯著的相關性,。遺傳標記是指在遺傳分析上用作標記的基因,，也稱為標記基因。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Genetics,， doi:10.1038/ng.275,，Mark S Silverberg，Richard H Duerr
Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
Mark S Silverberg1,22, Judy H Cho2,3,22, John D Rioux4, Dermot P B McGovern5, Jing Wu6, Vito Annese7, Jean-Paul Achkar8, Philippe Goyette4, Regan Scott9, Wei Xu10, M Michael Barmada11, Lambertus Klei12, Mark J Daly13, Clara Abraham2, Theodore M Bayless14, Fabrizio Bossa7, Anne M Griffiths15, Andrew F Ippoliti5, Raymond G Lahaie16, Anna Latiano7, Pierre Paré17, Deborah D Proctor2, Miguel D Regueiro9, A Hillary Steinhart1, Stephan R Targan5, L Philip Schumm18, Emily O Kistner18, Annette T Lee19, Peter K Gregersen19, Jerome I Rotter5,20, Steven R Brant14,21, Kent D Taylor5,20, Kathryn Roeder6 & Richard H Duerr9,11
Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry. In an analysis that controlled for gender and population structure, ulcerative colitis loci attaining genome-wide significance and subsequent replication in two independent populations were identified on chromosomes 1p36 (rs6426833, combined P = 5.1 10-13, combined odds ratio OR = 0.73) and 12q15 (rs1558744, combined P = 2.5 10-12, combined OR = 1.35). In addition, combined genome-wide significant evidence for association was found in a region spanning BTNL2 to HLA-DQB1 on chromosome 6p21 (rs2395185, combined P = 1.0 10-16, combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 10-8, combined OR = 0.56; rs10889677, combined P = 1.3 10-8, combined OR = 1.29).
