一個國際科研小組在最新一期英國《自然·遺傳學》雜志上報告說，他們新發(fā)現(xiàn)3個與兒童肥胖癥相關(guān)的基因變異，這將有助于醫(yī)學研究人員預測乃至治療兒童肥胖癥。
來自法國國家科研中心、英國倫敦帝國理工學院等機構(gòu)的研究人員介紹說，他們在這項長達10年的研究中,，對上千名6歲以下肥胖兒童及一些成年肥胖癥患者進行了全基因組關(guān)聯(lián)分析，這些成年研究對象都是從兒童期或青春期就開始出現(xiàn)肥胖癥狀的,。
研究人員將他們的基因信息與同年齡段正常體重者的基因信息對比,，結(jié)果識別出3個以前從未發(fā)現(xiàn)的基因變異，而50％的兒童肥胖癥患者都與這3個基因變異有關(guān),。
在這3個基因變異中,，與兒童肥胖癥以及成年肥胖癥關(guān)聯(lián)最密切的一個，位于PTER基因附近,，研究人員目前尚不清楚該基因的功能,。他們估計，兒童肥胖癥中有三分之一都可歸結(jié)到這個基因變異上,，成年肥胖癥中也有大約五分之一與它有關(guān),。
第二個基因變異位于NPC1基因中。此前以老鼠為對象的研究已經(jīng)表明，這個基因與食欲有關(guān),。研究人員估計,，兒童肥胖癥中有十分之一與這一基因變異相關(guān)。
第三個基因變異位于MAF基因附近,。該基因負責控制胰島素,、胰高血糖素及胰高血糖素樣肽的產(chǎn)生，這些激素和肽在人體葡萄糖和碳水化合物的代謝中都扮演關(guān)鍵角色,。兒童肥胖癥中大約有6％的病例與這個基因變異有關(guān),。
研究小組在報告中說，下一步,，他們將進行更深入的研究,，以確認這3個基因是否獨立發(fā)揮作用。他們表示,，新發(fā)現(xiàn)及以往在該領(lǐng)域的研究成果,，將有助于醫(yī)學界開發(fā)出基因工具，預測哪些兒童是“高危”肥胖兒,，并提前予以干預,，避免兒童出現(xiàn)肥胖癥狀,。(生物谷Bioon.com）
生物谷推薦原始出處：
Nature Genetics Published online: 18 January 2009 | doi:10.1038/ng.301
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
David Meyre1, Jér?me Delplanque1, Jean-Claude Chèvre1, Cécile Lecoeur1, Stéphane Lobbens1, Sophie Gallina1, Emmanuelle Durand1, Vincent Vatin1, Franck Degraeve1, Christine Proen?a1, Stefan Gaget1, Antje K?rner2, Peter Kovacs3, Wieland Kiess2, Jean Tichet4, Michel Marre5, Anna-Liisa Hartikainen6, Fritz Horber7, Natascha Potoczna7, Serge Hercberg8, Claire Levy-Marchal9, Fran?ois Pattou10, Barbara Heude11, Maithé Tauber12, Mark I McCarthy13,14,15, Alexandra I F Blakemore16, Alexandre Montpetit17, Constantin Polychronakos17, Jacques Weill18, Lachlan J M Coin19, Julian Asher16, Paul Elliott19, Marjo-Riitta J?rvelin19,20, Sophie Visvikis-Siest21, Beverley Balkau11, Rob Sladek17, David Balding19, Andrew Walley16, Christian Dina1 & Philippe Froguel1,16
We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 10-7), near MAF (encoding the transcription factor c-MAF, P = 3.8 10-13) and near PTER (phosphotriesterase-related gene, P = 2.1 10-7).
1 CNRS 8090-Institute of Biology, Pasteur Institute, 59000 Lille, France.
2 University Hospital for Children & Adolescents, University of Leipzig, 04103 Leipzig, Germany.
3 Interdisciplinary Centre for Clinical Research, University of Leipzig, 04103 Leipzig, Germany.
4 Institut Inter Régional pour la Santé, 37521 La Riche, France.
5 Department of Endocrinology, Diabetology, Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique des H?pitaux de Paris, 75018 Paris, France, and Institut National de la Santé et de la Recherche Médicale U695, 6 Université Paris 7, 75007 Paris, France.
7 Department of Clinical Sciences/ Obstetrics and Gynecology, University of Oulu, University of Oulu, 90014 Oulu, Finland.
8 Klinik Lindberg, 8400 Winterthur, and University of Berne, 3012 Berne, Switzerland.
9 Unité Mixte de Recherche U557 Institut National de la Santé et de la Recherche Médicale, U1125 Institut National de la 10 Recherche Agronomique, Conservatoire National des arts et Métiers, Université Paris 13, Centre de Recherches en 11 Nutrition Humaine Ile de France, F-93017 Bobigny, France.
12 Institut National de la Santé et de la Recherche Médicale, U690, Paris, FR-75019, France and Université Paris Diderot, Paris, FR-75205 cedex 13, France.
13 Institut National de la Santé et de la Recherche Médicale U859, Centre Hospitalier Régional Universitaire de Lille, 14 Lille North of France University, 59000 Lille France.
15 Institut National de la Santé et de la Recherche Médicale U780, Villejuif, F-94807; University Paris-Sud, Orsay, F-91405, France.
16 Institut National de la Santé et de la Recherche Médicale U563, Children's Hospital, Centre Hospitalier Universitaire 31000 Toulouse, France.
17 Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, OX3 7LJ Oxford, UK.
18 Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 Oxford, UK.
19 Oxford National Institute for Health Research Biomedical Research Centre, OX3 Oxford, UK.
20 Section of Genomic Medicine, Hammersmith Hospital, Imperial College London, W12 0HS London, UK.
21 McGill University and Genome Quebec Innovation Centre, H3A 1A Montreal, Canada.
22 Pediatric Endocrine Unit, Jeanne de Flandre Hospital, 59000 Lille, France.
23 Department of Epidemiology and Public Health, Imperial College London, WC1E 6BT London UK.
24 Institute of Health Sciences, University of Oulu, Department of Child and Adolescent Health, National Public Health 25 Institute, Biocenter Oulu, University of Oulu, 90014 Oulu, Finland.
26 Institut National de la Santé et de la Recherche Médicale "Cardiovascular Genetics" team, Centre D'investigation Clinique 54000 Nancy, France.
