洛克菲勒大學分子免疫學實驗室,，西奈山醫(yī)學院基因與細胞醫(yī)學系,，霍華休斯醫(yī)學院（HHMI）免疫學系的研究者在最新一期的Science雜志上發(fā)表封面文章，文章主要講述樹突狀細胞的發(fā)育機制,，文章標題：In Vivo Analysis of Dendritic Cell Development and Homeostasis,。
樹突狀細胞是由美國學者Steinman于1973年發(fā)現(xiàn)的，是目前所知的功能最強的抗原提呈細胞,，因其成熟時伸出許多樹突樣或偽足樣突起而得名,。樹突狀細胞（Dendritic cells, DC）是機體功能最強的專職抗原遞呈細胞(Antigen presenting cells, APC)，它能高效地攝取,、加工處理和遞呈抗原,，未成熟DC具有較強的遷移能力，成熟DC能有效激活初始型T細胞,，處于啟動,、調(diào)控、并維持免疫應答的中心環(huán)節(jié),。
樹突細胞根據(jù)其起源分為髓樣樹突細胞（myeloid dendritic cells,，MDC），和淋巴樣樹突細胞（Lymophiod dendritic cells,，LDC）,。對于淋巴樣樹突細胞而言，它與相同前體分化的核單核細胞系在發(fā)育前定居在什么地方,，如何從骨髓進入到外周淋巴器官這些機制一直不明,。
Michael的研究小組發(fā)現(xiàn)巨噬細胞和DC前體細胞逐漸發(fā)育成普通的DC前體細胞，普通的前體細胞發(fā)育成類漿DC細胞（Plasmacytoid DCs）和經(jīng)典的脾臟DCs（spleen DCs,，cDCs）,，最終定型為前體cDCs。前體cDCs細胞（Pre-cDCs）進入淋巴結(jié),，移行至高度內(nèi)皮化的小靜脈,，最終分散到淋巴結(jié)中，進入樹突細胞網(wǎng)絡定居下來,。關(guān)于cDC細胞發(fā)育的更深入的調(diào)節(jié)機制比如細胞周期等這些受調(diào)節(jié)性T細胞和fms樣絡氨酸激酶受體3有關(guān),。（生物谷Bioon.com）
生物谷推薦原始出處：
Science 17 April 2009:DOI: 10.1126/science.1170540
In Vivo Analysis of Dendritic Cell Development and Homeostasis
Kang Liu,1* Gabriel D. Victora,1 Tanja A. Schwickert,1 Pierre Guermonprez,1 Matthew M. Meredith,1 Kaihui Yao,1 Fei-Fan Chu,1 Gwendalyn J. Randolph,2 Alexander Y. Rudensky,3,4 Michel Nussenzweig1,4*
Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC network. Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3.
1 Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.
2 Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
3 Department of Immunology and Howard Hughes Medical Institute (HHMI), University of Washington, Seattle, WA 98195, USA.
4 HHMI, Rockefeller University, New York, NY 10021, USA.
