一項(xiàng)大規(guī)模國際研究顯示，某些出生時(shí)體重較輕的人成年后易患糖尿病是基因作用使然,，研究人員已確認(rèn)了與此有關(guān)的兩個(gè)基因,。
新一期英國《自然遺傳學(xué)》雜志刊登報(bào)告說，英國,、法國,、德國等多個(gè)國家的研究人員綜合分析了來自多項(xiàng)研究的3.8萬名歐洲人的基因和健康數(shù)據(jù)。結(jié)果發(fā)現(xiàn),，出生時(shí)體重較輕的人成年后易患Ⅱ型糖尿病,。過去，有關(guān)專家一直從母親懷孕時(shí)胎兒營養(yǎng)狀況的角度來解釋這一現(xiàn)象,，這次研究則確認(rèn)了這一現(xiàn)象背后也有基因的作用,。
報(bào)告說，名為ADCY5和CCNL1的兩個(gè)基因與出生體重和糖尿病都有關(guān)系,。這兩個(gè)基因有不同的變種,，那些攜帶致病基因變種的人，與攜帶普通基因變種的人相比,，患Ⅱ型糖尿病的風(fēng)險(xiǎn)要高出25％,，與此同時(shí)前者出生時(shí)的體重也會(huì)平均比后者輕113克。
參與研究的英國愛丁堡大學(xué)詹姆斯·威爾遜博士說,，確認(rèn)這兩個(gè)基因,，是解開出生體重與成年后患病關(guān)系之謎的第一步。不僅是糖尿病,，對(duì)于心臟病,、高血壓等疾病來說，這項(xiàng)研究都有助于探索其背后的生理原因,。
(生物谷Bioon.com)
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生物谷推薦原文出處：
Nature Genetics doi:10.1038/ng.567
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Rachel M Freathy1,60, Dennis O Mook-Kanamori2,3,4,60, Ulla Sovio5,60, Inga Prokopenko6,7,60, Nicholas J Timpson8,60, Diane J Berry9,60, Nicole M Warrington10,60, Elisabeth Widen11, Jouke Jan Hottenga12, Marika Kaakinen13,14, Leslie A Lange15, Jonathan P Bradfield16, Marjan Kerkhof17, Julie A Marsh10, Reedik M?gi6,7, Chih-Mei Chen18,19, Helen N Lyon20,21, Mirna Kirin22, Linda S Adair23, Yurii S Aulchenko3, Amanda J Bennett6, Judith B Borja24, Nabila Bouatia-Naji25,26, Pimphen Charoen5,27, Lachlan J M Coin5, Diana L Cousminer11, Eco J C de Geus12, Panos Deloukas28, Paul Elliott5, David M Evans8, Philippe Froguel25,29, The Genetic Investigation of ANthropometric Traits (GIANT) Consortium58, Beate Glaser8,30, Christopher J Groves6, Anna-Liisa Hartikainen31, Neelam Hassanali6, Joel N Hirschhorn20,32,33,34, Albert Hofman3, Jeff M P Holly35, Elina Hypp?nen9, Stavroula Kanoni36, Bridget A Knight37, Jaana Laitinen38, Cecilia M Lindgren6,7, The Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)58, Wendy L McArdle39, Paul F O'Reilly5, Craig E Pennell40, Dirkje S Postma41, Anneli Pouta42, Adaikalavan Ramasamy5,43, Nigel W Rayner6,7, Susan M Ring39, Fernando Rivadeneira3,44, Beverley M Shields37, David P Strachan45, Ida Surakka11, Anja Taanila13, Carla Tiesler18,19, Andre G Uitterlinden3,44, Cornelia M van Duijn3, The Wellcome Trust Case Control Consortium (WTCCC)58, Alet H Wijga46, Gonneke Willemsen12, Haitao Zhang16, Jianhua Zhao47, James F Wilson22, Eric A P Steegers48, Andrew T Hattersley37, Johan G Eriksson49,50,51,52, Leena Peltonen11,28,53,59, Karen L Mohlke15, Struan F A Grant16,47,54, Hakon Hakonarson16,47,54, Gerard H Koppelman55, George V Dedoussis36, Joachim Heinrich18, Matthew W Gillman56, Lyle J Palmer10, Timothy M Frayling1, Dorret I Boomsma12,61, George Davey Smith8,61, Chris Power9,61, Vincent W V Jaddoe2,3,61, Marjo-Riitta Jarvelin5,13,14,42,61 & Mark I McCarthy6,7,57,61 for the Early Growth Genetics (EGG) Consortium
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 × 10(-35)) and rs9883204 in ADCY5 (P = 7 × 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes1, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes2, 3 has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight–lowering alleles were, on average, 113 g (95% CI 89–137 g) lighter at birth than the 24% with zero or one alleles (Ptrend = 7 × 10(-30)). The impact on birth weight is similar to that of a mother smoking 4–5 cigarettes per day in the third trimester of pregnancy4
