生物谷報道本周Science再發(fā)一篇有關(guān)Prion蛋白的報道,這是Prion研究中的新進展,。有關(guān)它的報道在生物谷內(nèi)有多篇,。
Neuronal death is a prominent, but poorly understood, pathological hallmark of prion disease. Notably, in the absence of the cellular prion protein (PrPC), the disease-associated isoform, PrPSc, appears not to be intrinsically neurotoxic, suggesting that PrPC itself may participate directly in the prion neurodegenerative cascade. Here, cross-linking PrPC in vivo with specific monoclonal antibodies was found to trigger rapid and extensive apoptosis in hippocampal and cerebellar neurons. These findings suggest that PrPC functions in the control of neuronal survival and provides a model to explore whether cross-linking of PrPC by oligomeric PrPSc can promote neuronal loss during prion infection.
Original article:
Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo
Laura Solforosi, Jose R. Criado, Dorian B. McGavern, Sebastian Wirz, Manuel Sánchez-Alavez, Shuei Sugama, Lorraine A. DeGiorgio, Bruce T. Volpe, Erika Wiseman, Gil Abalos, Eliezer Masliah, Donald Gilden, Michael B. Oldstone, Bruno Conti, and R. Anthony Williamson
Science Mar 5 2004: 1514-1516. Published online January 29, 2004 [DOI: 10.1126/science.1094273] (in Science Express Reports ) [Abstract] [Full Text] [PDF] [Supporting Online Material]
Related article:
Prion蛋白是神經(jīng)細胞凋亡的關(guān)鍵
Prion Pathway
