美國研究人員２２日在Science雜志網(wǎng)絡(luò)版上報告說,，他們找到了帕金森病的發(fā)病機理，將來有望開發(fā)出治療帕金森病的新藥物,。
美國霍華德·休斯醫(yī)學(xué)研究所的蘇珊·林德奎斯特和南希·博尼尼與同事合作研究發(fā)現(xiàn),，大腦中一個關(guān)鍵的細(xì)胞生化途徑如果出現(xiàn)缺陷,，就會導(dǎo)致分泌多巴胺的神經(jīng)細(xì)胞死亡,。多巴胺是一種神經(jīng)遞質(zhì),，腦內(nèi)多巴胺缺乏，就會出現(xiàn)震顫、僵直,、運動遲緩等一系列帕金森病癥狀,。此外，她們還利用幾種帕金森病的動物模型,，找到了一種“拯救”瀕死神經(jīng)細(xì)胞的新方法。
林德奎斯特指出,，這一研究成果可以幫助人們尋找治療帕金森病等神經(jīng)退行性疾病的新方法,，加快新藥的開發(fā)進程。
參考資料：
DeKosky, S.T., and K. Marek. 2003. Looking backward to move forward: Early detection of neurodegenerative disorders. Science 302 (Oct. 31):830-834. Abstract available at http://www.sciencemag.org/cgi/content/abstract/302/5646/830.
Eckert, T., and D. Eidelberg. 2005. Neuroimaging and therapeutics in movement disorders. NeuroRx 2(April):361-371. Available at http://www.neurorx.org/article/PIIS1545534306700827/fulltext.
Huang, C. . . . and D. Eidelberg. 2006. Metabolic patterns associated with cognitive function. World Parkinson Congress. Feb. 22-26. Washington, DC. Abstract available at http://www.worldpdcongress.org/Program/
WPCProgram2006final.pdf.
Mhyre, T. . . . and H. J. Federoff. 2006. Proteomic analysis of peripheral leukocytes in neurodegenerative diseases. World Parkinson Congress. Feb. 22-26. Washington, DC. Abstract available at http://www.worldpdcongress.org/Program/
WPCProgram2006final.pdf.
Tang, C. . . . and D. Eidelberg. 2006. Assess metabolic brain networks by cerebral blood flow measurement: A H20 and FDG PET study. World Parkinson Congress. Feb. 22-26. Washington, DC. Abstract available at http://www.worldpdcongress.org/Program/
WPCProgram2006final.pdf.
Further Readings:
Brownlee, C. 2005. Pumping out hope: Stem cells secrete brain-preserving protein. Science News 168(Dec. 24):403. Available to subscribers at http://www.sciencenews.org/articles/20051224/fob2.asp.
______. 2005. Inner-brain electrode may curb depression. Science News 167(March 12):174. Available to subscribers at http://www.sciencenews.org/articles/20050312/note14.asp.
Seppa, N. 2002. Imaging Parkinson's. Science News 162(Dec. 14):382. Available to subscribers at http://www.sciencenews.org/articles/20021214/note14.asp.
