敵意、發(fā)火和沮喪這些糟糕的情緒變化似乎不是那么可怕,，但它們可能會(huì)對(duì)我們的健康帶來一些負(fù)面影響,，比如說心臟病、糖尿病和高血壓,。
《大腦行為與免疫》（Brain Behavior and Immunity）是愛思唯爾出版集團(tuán)旗下的一份期刊,。在最新出版的一期中，研究者介紹了如下試驗(yàn)：313名男子參加了一項(xiàng)空軍健康研究項(xiàng)目,，旨在測(cè)定敵意,、發(fā)火和沮喪這些情緒變化是否會(huì)引起人體內(nèi)C3蛋白含量的變化。C3蛋白質(zhì)是控制油脂和葡萄糖代謝的一種主要蛋白,，和心血管疾病以及糖尿病有關(guān),。這類體檢連續(xù)進(jìn)行了20年，研究者根據(jù)有關(guān)測(cè)驗(yàn)收集到所需要的信息,，然后對(duì)他們的個(gè)性特征,、心理因素以及罹患各種慢性疾病的風(fēng)險(xiǎn)進(jìn)行評(píng)估。在1992,、1997和2002三個(gè)年份中,，研究者還對(duì)受試者體內(nèi)的C3蛋白和C4蛋白進(jìn)行了評(píng)估。
根據(jù)對(duì)這些中年健康男性的長(zhǎng)時(shí)間研究,，研究者發(fā)現(xiàn),，對(duì)敵意、發(fā)火和沮喪等情緒變化的測(cè)定,，很好地預(yù)測(cè)了10年中C3蛋白的增加趨勢(shì),。他們認(rèn)為，這些數(shù)據(jù)有力地佐證了如下的規(guī)律：情緒,，比如敵意,、發(fā)火和沮喪，是和長(zhǎng)期的炎癥形成過程息息相關(guān),，而炎癥會(huì)導(dǎo)致冠狀心臟病,、糖尿病和高血壓。
總而言之,，當(dāng)危及到健康時(shí),，我們就應(yīng)該對(duì)敵意,、發(fā)火和沮喪的情緒進(jìn)行快速的調(diào)整。否則,，長(zhǎng)期下來，我們就可能因此而倒霉了,。
部分英文原文：
Brain, Behavior, and Immunity, In Press, Corrected Proof, Available online 23 February 2007,
Hostility, anger, and depression predict increases in C3 over a 10-year period
Stephen H. Boylea, , , William G. Jacksonb and Edward C. Suareza, ,
aDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, P.O. Box 3328, Durham, NC 27710, USA
bAir Force Research Laboratory Brooks-City Base, TX, USA
Received 30 June 2006; revised 9 January 2007; accepted 12 January 2007. Available online 23 February 2007.
Abstract
We examined the relation of hostility, anger, and depression to 10-year changes in the third (C3), and fourth (C4) complement in 313, apparently healthy male participants enrolled in the Air Force Health Study (AFHS), a 20-year study designed to evaluate the health consequences of dioxin exposure. Hostility, depression, and anger were assessed using subscales from the Minnesota Multiphasic Personality Inventory (MMPI), which was administered in 1985. Given the high intercorrelations among these psychological scales, we used a principal component analysis to generate a composite score representing the linear combination of the hostility, anger, and depression scales. The dependent variables, C3 and C4 levels, were determined from samples collected in 1992, 1997, and 2002. Regression analyses controlling for age, race, alcohol use, body mass index, and cigarette use as well as onset of disease, and use of lipid lowering and blood pressure medications during follow-up revealed a significant time × composite score interaction for C3 complement (p < .0003), but not C4. Post-hoc analyses revealed that high composite scores were associated with larger 10-year increases in C3. These observations suggest that men who are hostile and are prone to experience frequent and intense feelings of anger, and depression show activation of the complement system, and specifically increases in C3, that may contribute to the development of coronary heart disease.
Keywords: Complement; Hostility; Anger; Depression; Men
Corresponding authors. Fax: +1 919 668 6419.
