在一項(xiàng)新的動(dòng)物研究中,，密西根大學(xué)的研究人員表示,，在暴露于噪音前一個(gè)小時(shí)，服用維生素A,、C,、和E及鎂的大劑量組合，并且每天服用一次連續(xù)服用五天,，對(duì)于防止噪音造成的聽(tīng)力永久損失,，是相當(dāng)有效的。
這種聽(tīng)力保護(hù)藥片或點(diǎn)心,，將會(huì)很快地進(jìn)行人體的臨床試驗(yàn),，如果這種產(chǎn)品的臨床試驗(yàn)成功，將于二年內(nèi)上市,。這篇研究發(fā)表于Free Radical Biology and Medicine中,。
研究作者Josef M. Miller表示，許多研究證據(jù)顯示,，營(yíng)養(yǎng)素可以阻止噪音造成的聽(tīng)力喪失,，噪音會(huì)使得內(nèi)耳的自由基活性過(guò)高而造成聽(tīng)力損失,。氧自由基與噪音傷害有關(guān)。噪音暴露后,，氧自由基釋放至毛細(xì)胞,，并轉(zhuǎn)變?yōu)闃O具破壞力的氫氧自由基。因此噪音暴露后,，抗氧化物可以預(yù)防暫時(shí)性聽(tīng)力損失,。
這項(xiàng)研究結(jié)果建議，無(wú)法避免暴露于噪音環(huán)境中的人們,，例如軍人,、飛行員、建筑工人等,，可以在早上接受這種多合一營(yíng)養(yǎng)補(bǔ)充法的治療,，使聽(tīng)力損傷減到最小。
(資料來(lái)源 : Bio.com)
英文原文：
Public release date: 28-Mar-2007
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University of Michigan Health System
Nutrients might prevent hearing loss, new animal study suggests
Antioxidant-mineral combination protects against damage for days after noise exposure, U-M study in guinea pigs shows
This release is available in Spanish.
Colleen Le Prell and Josef M. Miller, the lead and senior authors of new research on the use of nutrients to prevent hearing loss in guinea pigs.
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ANN ARBOR, Mich. -- Soldiers exposed to the deafening din of battle have little defense against hearing loss, and are often reluctant to wear protective gear like ear plugs that could make them less able to react to danger. But what if a nutritious daily "candy bar" could prevent much of that potential damage to their hearing?
In a new study in animals, University of Michigan researchers report that a combination of high doses of vitamins A, C, and E and magnesium, taken one hour before noise exposure and continued as a once-daily treatment for five days, was very effective at preventing permanent noise-induced hearing loss. The animals had prolonged exposure to sounds as loud as a jet engine at take-off at close range.
Clinical trials of a hearing-protection tablet or snack bar for people could begin soon, and if successful such a product could be available in as little as two years, says Josef M. Miller, Ph.D., the senior author of the study, which is published online in the journal Free Radical Biology and Medicine. Miller is a professor in the Department of Otolaryngology at the U-M Medical School, and former director of the U-M Health System抯 Kresge Hearing Research Institute, where the study was performed.
Convinced by emerging evidence that nutrients can effectively block one major factor in hearing loss after noise trauma ?inner ear damage caused by excessive free radical activity ?Miller has launched a U-M startup company OtoMedicine that is developing the vitamin-and-magnesium formulation.
"These agents have been used for many years, but not for hearing loss. We know they抮e safe, so that opens the door to push ahead with clinical trials with confidence we抮e not going to do any harm," says Miller.
The formulation the researchers used built on earlier animal studies showing that single antioxidant vitamins were somewhat effective in preventing hearing loss, and on studies of Israeli soldiers given magnesium many days prior to exposure, who gained relatively small protective effects.
In the U-M study, noise-induced hearing loss was measured in four groups of guinea pigs treated with the antioxidant vitamins A, C and E, magnesium alone, an ACE-magnesium combination, or a placebo. The treatments began one hour before a five-hour exposure to 120 decibel (dB) sound pressure level noise, and continued once daily for five days.
The group given the combined treatments of vitamins A, C and E and magnesium showed significantly less noise-induced hearing loss than all of the other groups.
"Vitamins A, C and E and magnesium worked in synergy to prevent cell damage," explains Colleen G. Le Prell, Ph.D., the study抯 lead author and a research investigator at the U-M Kresge Hearing Research Institute. According to the researchers, pre-treatment presumably reduced reactive elements called free radicals that form during and after noise exposure and noise-induced constriction of blood flow to the inner ear, and may have also reduced neural excitotoxicity, or the damage to auditory neurons that can occur due to over-stimulation. The post-noise nutrient doses apparently "scavenged" free radicals that continue to form long-after after this noise exposure ends.
In the past 10 years, scientists have learned that noise-induced hearing loss occurs in part because cell mitochondria in the ear churn out damaging free radicals in response to loud sounds. "Free radical formation bursts initially, then peaks again during the days after exposure," explains Le Prell.
The antioxidant vitamins and magnesium used in the study are widely used dietary supplements, not new drugs, and therefore they don抰 require the extensive safety tests required for new drug entities prior to use in clinical trials. The doses to be used in proposed human trials will be within the ranges considered safe according to the Institute of Medicine and federal nutrition guidelines.
"Ultimately, we envision soldiers would have a nutritional bar with meals and it would give them adequate daily protection," says Miller. Similar bars with other formulations are already given to soldiers to help them withstand hot weather and other war zone conditions.
"Other people would likely benefit by consuming a pill or nutritional bar before going to work in noisy environments, or attending noisy events like NASCAR races or rock concerts, or even using an iPod or other music player," says Le Prell. "Based on an earlier study with other antioxidant agents, we think this micronutrient combination will work even post-noise."
That study suggested a "morning after" treatment, that might minimize hearing damage for soldiers, musicians, pilots, construction workers and others ?even if they don抰 take it until after they experience dangerous noise levels. It was highlighted by the National Institutes of Health on the NIDCD website at www.nidcd.nih.gov/research/stories/archives/06/08_01_06.asp.
If effective, such pre- and post-noise treatments could have far-reaching effects. About 30 million Americans regularly experience hazardous noise levels at work and at home, according to the National Institute on Deafness and Communications Disorders. Hunting, snowmobiling, using machines such as leaf blowers, lawnmowers and power tools, and attending or playing in loud music concerts commonly expose people to dangerous noise levels. Noise levels above 85 decibels damage hearing. About 28 million Americans have some degree of hearing loss. For about a third of them, noise accounts at least in part for their loss.
The U-M study also adds strength to research efforts under way in many research centers to learn how these nutrients might be used to treat many illnesses. "Similar combinations have been very effective in preventing macular degeneration, and many of these agents have been used with Alzheimer抯 and Parkinson抯 diseases, stroke-like ischemia, and other conditions that involve neural degeneration," Le Prell says. "You抮e always hoping as a basic scientist to find a commonality like that, across other disease processes," says Miller.
U-M has applied for patents covering the use of this unique combination of vitamins and minerals in the prevention of hearing loss, as demonstrated in this study; if and when revenues are generated as a result of these commercialization efforts, the University and the inventors of the technology stand to benefit financially. An additional author of the study is Larry F. Hughes, Dept. of Surgery/Otolaryngology, Southern Illinois University Medical School. The study was supported with funds from the National Institutes of Health, General Motors Corporation/United Automotive Workers Union, and the Ruth and Lynn Townsend Professorship in Communication Disorders. Reference: Free Radical Biology & Medicine, 42 (2007) 1454?463
