生物谷報(bào)道：研究人員發(fā)現(xiàn)，一種神經(jīng)傳遞受體的編碼基因的普通變異會促進(jìn)情感記憶能力的提高,，這一最新的研究成果發(fā)表在9月號的《自然—神經(jīng)科學(xué)》上,。
負(fù)責(zé)編碼阿爾法2b腎上腺素受體的基因會出現(xiàn)變異,，30%的高加索人和12%的非洲裔美國人會攜帶這種變異基因，他們表現(xiàn)出對情感圖片有更好的記憶力,。Dominique de Quervain和同事將情感呈中性,、正面和負(fù)面的圖片展現(xiàn)在健康的瑞士受試者前，他們發(fā)現(xiàn),，與正常人相比,，攜帶這種變異基因的人更可能記住正面和負(fù)面的情感圖像，而兩組人對情感中性的圖片的記憶力沒有表現(xiàn)出不同,。
在對盧旺達(dá)難民的另一項(xiàng)測試中,，研究人員發(fā)現(xiàn)，盡管創(chuàng)傷后應(yīng)激障礙的診斷沒有與基因型結(jié)合起來,，但攜帶這種變異基因的人對來自戰(zhàn)爭的情感記憶更為深刻和長久,。（科學(xué)時(shí)報(bào)）
原始出處:
Nature Neuroscience
Published online: 29 July 2007; | doi:10.1038/nn1945
A deletion variant of the 2b-adrenoceptor is related to emotional memory in Europeans and Africans
Dominique J-F de Quervain1, 2, Iris-Tatjana Kolassa3, Verena Ertl3, P Lamaro Onyut3, 4, Frank Neuner3, Thomas Elbert3 & Andreas Papassotiropoulos5, 6
1 Division of Psychiatry Research, University of Zürich, Lenggstr. 31, 8032 Zürich, Switzerland.
2 Center for Integrative Human Physiology, University of Zürich, 8057, Zürich, Switzerland.
3 Department of Psychology, University of Konstanz, D25, 78457 Konstanz, Germany.
4 Faculty of Science and Education, Mbarara University of Science & Technology, P.O. Box 1410, Mbarara, Uganda.
5 Division of Molecular Psychology, University of Basel, Missionsstr. 62a, 4055 Basel, Switzerland.
6 Life Sciences Training Facility, Biozentrum, University of Basel, Klingelbergstr. 50/70, 4056 Basel, Switzerland.
Correspondence should be addressed to Dominique J-F de Quervain [email protected] or Andreas Papassotiropoulos [email protected]
Emotionally arousing events are recalled better than neutral events. This phenomenon, which helps us to remember important and potentially vital information, depends on the activation of noradrenergic transmission in the brain. Here we show that a deletion variant of ADRA2B, the gene encoding the 2b-adrenergic receptor, is related to enhanced emotional memory in healthy Swiss subjects and in survivors of the Rwandan civil war who experienced highly aversive emotional situations.
