感覺信息是通過大腦對(duì)運(yùn)動(dòng)與感覺之間的協(xié)調(diào)互動(dòng)作用來(lái)進(jìn)行采集與處理的,。Ferezou研究小組利用電壓敏感染料直接對(duì)小鼠的軀體感覺和相應(yīng)的大腦感覺運(yùn)動(dòng)皮層進(jìn)行成像,。這項(xiàng)研究首次提供了大腦皮層對(duì)感覺運(yùn)動(dòng)的綜合圖像,，揭示了高度動(dòng)態(tài)和分布式處理過程與軀體行為的關(guān)聯(lián)。相關(guān)論文以封面文章的形式發(fā)表在2007年12月6日的《神經(jīng)元》（Neuron）上,。
軀體感覺往往源于觸摸物體時(shí)主動(dòng)產(chǎn)生的軀體運(yùn)動(dòng),，而感覺信息則是用來(lái)改進(jìn)和控制這些運(yùn)動(dòng)。因此,，在感覺與運(yùn)動(dòng)相互作用之間必然有一個(gè)重要的途徑,，F(xiàn)erezou等選擇了小鼠的腮須運(yùn)動(dòng)系統(tǒng)作為研究對(duì)象。他們利用電壓敏感染料在小鼠的大腦皮層,，通過類似柱形的空間分辨率和毫秒的時(shí)間精度的對(duì)大腦皮層感覺運(yùn)動(dòng)的膜電壓的動(dòng)態(tài)變化直接成像。研究表明：?jiǎn)蝹€(gè)腮須短促的位置偏移就會(huì)引起高度分布式極化皮質(zhì)感覺的反應(yīng),，由此開始了在初級(jí)體感桶型大腦皮質(zhì)及隨后的興奮腮須運(yùn)動(dòng)皮層,。腮須運(yùn)動(dòng)以及引起該運(yùn)動(dòng)的感覺能夠動(dòng)態(tài)地調(diào)節(jié)感覺信息到運(yùn)動(dòng)皮層的傳遞過程。大腦皮質(zhì)感覺運(yùn)動(dòng)的過程可能大大有助于人們對(duì)觸覺的認(rèn)知,。（科學(xué)網(wǎng)）
原始出處:
Neuron, Vol 56, 907-923, 06 December 2007
Spatiotemporal Dynamics of Cortical Sensorimotor Integration in Behaving Mice
Isabelle Ferezou,1,3 Florent Haiss,2 Luc J. Gentet,1 Rachel Aronoff,1 Bruno Weber,2 and Carl C.H. Petersen1,
1 Laboratory of Sensory Processing, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland
2 Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
Corresponding author
Carl C.H. Petersen
[email protected]
Summary
Tactile information is actively acquired and processed in the brain through concerted interactions between movement and sensation. Somatosensory input is often the result of self-generated movement during the active touch of objects, and conversely, sensory information is used to refine motor control. There must therefore be important interactions between sensory and motor pathways, which we chose to investigate in the mouse whisker sensorimotor system. Voltage-sensitive dye was applied to the neocortex of mice to directly image the membrane potential dynamics of sensorimotor cortex with subcolumnar spatial resolution and millisecond temporal precision. Single brief whisker deflections evoked highly distributed depolarizing cortical sensory responses, which began in the primary somatosensory barrel cortex and subsequently excited the whisker motor cortex. The spread of sensory information to motor cortex was dynamically regulated by behavior and correlated with the generation of sensory-evoked whisker movement. Sensory processing in motor cortex may therefore contribute significantly to active tactile sensory perception.
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