感覺信息是通過大腦對運(yùn)動與感覺之間的協(xié)調(diào)互動作用來進(jìn)行采集與處理的,。Ferezou研究小組利用電壓敏感染料直接對小鼠的軀體感覺和相應(yīng)的大腦感覺運(yùn)動皮層進(jìn)行成像,。這項(xiàng)研究首次提供了大腦皮層對感覺運(yùn)動的綜合圖像,，揭示了高度動態(tài)和分布式處理過程與軀體行為的關(guān)聯(lián),。相關(guān)論文以封面文章的形式發(fā)表在2007年12月6日的《神經(jīng)元》（Neuron）上,。

軀體感覺往往源于觸摸物體時主動產(chǎn)生的軀體運(yùn)動,，而感覺信息則是用來改進(jìn)和控制這些運(yùn)動,。因此,，在感覺與運(yùn)動相互作用之間必然有一個重要的途徑,，F(xiàn)erezou等選擇了小鼠的腮須運(yùn)動系統(tǒng)作為研究對象。他們利用電壓敏感染料在小鼠的大腦皮層,，通過類似柱形的空間分辨率和毫秒的時間精度的對大腦皮層感覺運(yùn)動的膜電壓的動態(tài)變化直接成像,。研究表明：單個腮須短促的位置偏移就會引起高度分布式極化皮質(zhì)感覺的反應(yīng)，由此開始了在初級體感桶型大腦皮質(zhì)及隨后的興奮腮須運(yùn)動皮層。腮須運(yùn)動以及引起該運(yùn)動的感覺能夠動態(tài)地調(diào)節(jié)感覺信息到運(yùn)動皮層的傳遞過程,。大腦皮質(zhì)感覺運(yùn)動的過程可能大大有助于人們對觸覺的認(rèn)知,。（科學(xué)網(wǎng)）

原始出處:

Neuron, Vol 56, 907-923, 06 December 2007

Spatiotemporal Dynamics of Cortical Sensorimotor Integration in Behaving Mice

Isabelle Ferezou,1,3 Florent Haiss,2 Luc J. Gentet,1 Rachel Aronoff,1 Bruno Weber,2 and Carl C.H. Petersen1,

1 Laboratory of Sensory Processing, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland
2 Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland

Corresponding author
Carl C.H. Petersen
[email protected]

Summary

Tactile information is actively acquired and processed in the brain through concerted interactions between movement and sensation. Somatosensory input is often the result of self-generated movement during the active touch of objects, and conversely, sensory information is used to refine motor control. There must therefore be important interactions between sensory and motor pathways, which we chose to investigate in the mouse whisker sensorimotor system. Voltage-sensitive dye was applied to the neocortex of mice to directly image the membrane potential dynamics of sensorimotor cortex with subcolumnar spatial resolution and millisecond temporal precision. Single brief whisker deflections evoked highly distributed depolarizing cortical sensory responses, which began in the primary somatosensory barrel cortex and subsequently excited the whisker motor cortex. The spread of sensory information to motor cortex was dynamically regulated by behavior and correlated with the generation of sensory-evoked whisker movement. Sensory processing in motor cortex may therefore contribute significantly to active tactile sensory perception.

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