生物谷援引新華網(wǎng)斯德哥爾摩１月６日電（記者 吳平）瑞典《每日新聞》日前報(bào)道說,，瑞典研究人員開展的一項(xiàng)大規(guī)模研究結(jié)果表明,，精神分裂癥等精神病癥與腦部病毒感染存在一定相關(guān)性。
據(jù)報(bào)道,，瑞典卡羅林斯卡醫(yī)學(xué)院研究人員對(duì)１９７３年至１９８５年期間出生的１２０多萬名瑞典人進(jìn)行研究后得出了以上結(jié)論,。這是世界
范圍內(nèi)迄今開展的最大規(guī)模的類似研究。１２０多萬名研究對(duì)象中有９０００人在１３歲前曾患有腦炎,，其中又有約２３００人患有精神分裂癥或其他精神病癥,。
腦炎主要由病毒或細(xì)菌感染引起。對(duì)比研究表明,，精神分裂癥等精神病癥與引發(fā)腦炎的細(xì)菌感染沒有關(guān)聯(lián),，但與引發(fā)腦炎的病毒感染存在一定相關(guān)性。例如研究中發(fā)現(xiàn),，感染巨細(xì)胞病毒引發(fā)腦炎的人精神分裂癥的患病風(fēng)險(xiǎn)比普通人高出６０％,，感染腮腺炎病毒引發(fā)腦炎的人患精神分裂癥風(fēng)險(xiǎn)比普通人高出一倍。
不過研究也顯示,，只有特定腦部病毒感染會(huì)增加人患精神分裂癥等精神病癥的風(fēng)險(xiǎn),，這些引發(fā)感染的病毒通常擁有侵入大腦軟組織的能力。研究人員指出,，精神分裂癥等精神病癥主要可能還是由遺傳因素引起的,，腦部病毒感染在其中所起的作用可能并不是很大。
這一研究結(jié)果已在今年第一期《美國精神病學(xué)雜志》上發(fā)表,。
生物谷推薦原始出處：
Am J Psychiatry 2008; 165:59-65
(published online December 3, 2007; doi: 10.1176/appi.ajp.2007.07050740)
Infections in the CNS During Childhood and the Risk of Subsequent Psychotic Illness: A Cohort Study of More Than One Million Swedish Subjects
Christina Dalman, M.D., Ph.D., Peter Allebeck, M.D., Ph.D., David Gunnell, M.B., Ch.B., Ph.D., Glyn Harrison, M.D., F.R.C.Psych., Krister Kristensson, M.D., Ph.D., Glyn Lewis, M.D., Ph.D., Sofia Lofving, B.Sc., Finn Rasmussen, M.D., Ph.D., Susanne Wicks, B.Sc., and Håkan Karlsson, Ph.D.
OBJECTIVE: Infections during early life have been suggested to play a role in the etiology of schizophrenia. Most studies have focused on fetal life; few have explored risk associated with infection during childhood. The results of these have been inconsistent. The present study aims to investigate whether there is an increased risk of schizophrenia and other nonaffective psychoses associated with viral or bacterial CNS infections during childhood and, if so, which specific agents are involved. METHOD: A national cohort consisting of 1.2 million children born between 1973 and 1985 was followed up by using Swedish national registers to retrieve data on hospital admissions for CNS infections at 0–12 years of age (bacterial: N=2,435, viral: N=6,550) as well as admissions for nonaffective psychotic illnesses from the 14th birthday (N=2,269). RESULTS: There was a slightly increased risk of nonaffective psychotic illness associated with viral CNS infections, as well as schizophrenia. There was no evidence of increased risk in relation to bacterial infections. When divided into specific agents, exposures to mumps virus or cytomegalovirus were associated with subsequent psychoses. CONCLUSIONS: Serious viral CNS infections during childhood appear to be associated with the later development of schizophrenia and nonaffective psychoses. The association with specific viruses suggests that the risk is related to infectious agents with a propensity to invade the brain parenchyma. （生物谷編輯：Lily）
