英國(guó)《泰晤士報(bào)》日前報(bào)道說(shuō),，最新的研究顯示,，一種從紅辣椒中提取的新型止痛藥可能妨礙學(xué)習(xí)和記憶等腦功能,。
制藥公司一直在試驗(yàn)這種利用紅辣椒中的烈性化合物辣椒素的暫時(shí)鎮(zhèn)痛作用研制的藥物。研制該藥物的目的只是為了抑制向大腦發(fā)送疼痛信號(hào)的神經(jīng),，但老鼠試驗(yàn)表明,，這種鎮(zhèn)痛
作用可能會(huì)導(dǎo)致連鎖反應(yīng)。
美國(guó)研究人員在《神經(jīng)元》雜志上發(fā)表文章說(shuō),，該藥物會(huì)作用于一個(gè)叫做ＴＲＰＶＩ的大腦感受器,，ＴＲＰＶＩ既控制痛感，還主要控制著情緒和記憶的過(guò)程,。該發(fā)現(xiàn)可能也有助于解釋減肥藥Ａｃｏｍ?。穑欤椋釢撛诘淖詺⑿愿弊饔谩?/p>
生物谷推薦原始出處：
Neuron, Vol 57, 629-631, 13 March 2008
Hotheaded: TRPV1 as Mediator of Hippocampal Synaptic Plasticity
Benedict J. Alter1 and Robert W. Gereau IV1,
1 Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Summary
TRPV1 is a sensory transduction channel that mediates thermal nociception and some aspects of pathological pain. In this issue of Neuron, Gibson et al. report that TRPV1 also plays important roles in hippocampal synaptic plasticity, presenting a potential challenge for TRPV1-targeted therapeutics for the treatment of pain.
