研究人員報(bào)道說(shuō),，抗抑郁藥fluoxetine可以使成年大鼠腦中的與視覺(jué)有關(guān)的神經(jīng)元回復(fù)到它們年輕時(shí)的更具可塑性的狀態(tài),，并使其能夠從某些類型的視覺(jué)損害中康復(fù),。相關(guān)論文發(fā)表在4月18日的《科學(xué)》雜志上,。這一發(fā)現(xiàn)表明,，fluoxetine可能對(duì)治療成年人的弱視（也被稱為“懶眼癥”,，是一種常見(jiàn)的眼疾）有用,，罹患該病的患者的一只眼睛比另外一只要弱,，因?yàn)檩^弱的那只眼睛在患者孩童期的早期未被充分使用。
新結(jié)果還為一個(gè)尚未得到解答的問(wèn)題提供了線索,，即抗抑郁藥是如何幫助調(diào)整抑郁癥患者的情緒的,，因?yàn)樵摼€索提示腦可塑性可能是該疾病的一個(gè)重要部分。
實(shí)驗(yàn)中,，José Fernando Maya Vetencourt及其在意大利和芬蘭的同僚給成年大鼠喂食常規(guī)劑量的fluoxetine,，而這些成年大鼠的視力已經(jīng)受到損害，因?yàn)樵谒鼈冊(cè)缒臧l(fā)育的關(guān)鍵時(shí)期,，它們的眼睛缺少與視覺(jué)圖像的接觸,。研究人員發(fā)現(xiàn)，大鼠腦中的蛋白質(zhì)表達(dá)及電信號(hào)在治療后發(fā)生了變化,，表明這種治療已經(jīng)使大鼠視覺(jué)系統(tǒng)神經(jīng)元的可塑性得到恢復(fù)并促進(jìn)了大鼠視覺(jué)的康復(fù),。（來(lái)源：Eurekalert！中文版）
生物谷推薦原始出處：
（Science）,，Vol. 320. no. 5874, pp. 385 - 388,，José Fernando Maya Vetencourt, Lamberto Maffei
The Antidepressant Fluoxetine Restores Plasticity in the Adult Visual Cortex
José Fernando Maya Vetencourt,1* Alessandro Sale,1 Alessandro Viegi,1 Laura Baroncelli,1 Roberto De Pasquale,1 Olivia F. O'Leary,3 Eero Castrén,3 Lamberto Maffei1,2
We investigated whether fluoxetine, a widely prescribed medication for treatment of depression, restores neuronal plasticity in the adult visual system of the rat. We found that chronic administration of fluoxetine reinstates ocular dominance plasticity in adulthood and promotes the recovery of visual functions in adult amblyopic animals, as tested electrophysiologically and behaviorally. These effects were accompanied by reduced intracortical inhibition and increased expression of brain-derived neurotrophic factor in the visual cortex. Cortical administration of diazepam prevented the effects induced by fluoxetine, indicating that the reduction of intracortical inhibition promotes visual cortical plasticity in the adult. Our results suggest a potential clinical application for fluoxetine in amblyopia as well as new mechanisms for the therapeutic effects of antidepressants and for the pathophysiology of mood disorders.
