美國研究人員發(fā)現(xiàn)，塑料中普遍含有的一種化學(xué)物質(zhì)“雙酚A”與猴子大腦功能失常和情緒紊亂有關(guān),。
雙酚A簡稱BPA,，被廣泛應(yīng)用于塑料制造，包括飲料瓶,、食品容器和奶瓶等,。BPA可從塑料制品中滲透到食品和水中，關(guān)于BPA是否危害人類尤其是未成年人健康的爭議由來已久,，這是對BPA可能有害健康所進行的一系列研究中最新一項,。此前有老鼠試驗表明，BPA與行為變化,、大腦變化和青春期提前等有關(guān),。
美國耶魯大學(xué)醫(yī)學(xué)院研究人員在最新一期《國家科學(xué)院學(xué)報》上報告說，試驗中,，他們讓年輕的非洲綠猴接觸的雙酚Ａ含量處于美國環(huán)保局認為對人體安全的標準之內(nèi),，結(jié)果發(fā)現(xiàn)這種化學(xué)物質(zhì)影響猴子大腦中海馬區(qū)和前額葉兩個關(guān)鍵區(qū)域的神經(jīng)連接，對于認知和情緒控制具有干擾作用,。
負責(zé)國家毒理學(xué)計劃的助理局長約翰·布赫說：“這些在動物試驗中看到的變化是否直接適用于人類,、是否會導(dǎo)致明顯有害于健康的影響還存在很大的不確定性。但我們的結(jié)論是,，不能排除BPA會影響人類發(fā)育的可能性,。”
研究人員說，基于這些發(fā)現(xiàn),，他們認為美國環(huán)保局要考慮降低人類BPA接觸量的安全值,。（生物谷Bioon.com）
生物谷推薦原始出處：
PNAS Published online before print September 3, 2008, doi: 10.1073/pnas.0806139105
Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates
Csaba Leranth*,, Tibor Hajszan*, Klara Szigeti-Buck*, Jeremy Bober*, and Neil J. MacLusky
Exposure measurements from several countries indicate that humans are routinely exposed to low levels of bisphenol A (BPA), a synthetic xenoestrogen widely used in the production of polycarbonate plastics. There is considerable debate about whether this exposure represents an environmental risk, based on reports that BPA interferes with the development of many organs and that it may alter cognitive functions and mood. Consistent with these reports, we have previously demonstrated that BPA antagonizes spine synapse formation induced by estrogens and testosterone in limbic brain areas of gonadectomized female and male rats. An important limitation of these studies, however, is that they were based on rodent animal models, which may not be representative of the effects of human BPA exposure. To address this issue, we examined the influence of continuous BPA administration, at a daily dose equal to the current U.S. Environmental Protection Agency's reference safe daily limit, on estradiol-induced spine synapse formation in the hippocampus and prefrontal cortex of a nonhuman primate model. Our data indicate that even at this relatively low exposure level, BPA completely abolishes the synaptogenic response to estradiol. Because remodeling of spine synapses may play a critical role in cognition and mood, the ability of BPA to interfere with spine synapse formation has profound implications. This study is the first to demonstrate an adverse effect of BPA on the brain in a nonhuman primate model and further amplifies concerns about the widespread use of BPA in medical equipment, and in food preparation and storage.
