近日,，中科院心理所陳楚僑研究員課題組用元分析方法發(fā)現(xiàn)小腦在運(yùn)動(dòng)協(xié)調(diào)任務(wù)中的激活模式。相關(guān)論文發(fā)表在愛(ài)思唯爾期刊《大腦研究評(píng)論》上,。
以往大量的研究都在試圖通過(guò)觀測(cè)運(yùn)動(dòng)協(xié)調(diào)比如同步的重復(fù)手指運(yùn)動(dòng)的腦功能激活模式來(lái)考察小腦在運(yùn)動(dòng)協(xié)調(diào)任務(wù)中起到一個(gè)什么樣的作用,。然而，不同的研究方法和分析策略揭示了各式各樣的腦功能激活模式,，都沒(méi)有一個(gè)統(tǒng)一確定的結(jié)果,。在先前研究中大家一般一致認(rèn)同的是，復(fù)雜的運(yùn)動(dòng)產(chǎn)生了初級(jí)運(yùn)動(dòng)皮層和感覺(jué)區(qū)域的激活,，也帶動(dòng)了與運(yùn)動(dòng)相聯(lián)系的區(qū)域和小腦的激活,。然而，大多數(shù)這樣的研究要么局限于一個(gè)單獨(dú)的順序任務(wù)或者僅僅局限于單個(gè)手指運(yùn)動(dòng),。很少有研究去整合運(yùn)動(dòng)任務(wù)復(fù)雜性的不同水平下小腦激活模式和強(qiáng)度,。運(yùn)動(dòng)任務(wù)復(fù)雜性的不同水平可以包括運(yùn)動(dòng)成分不同特征之間的特定對(duì)比，比如扣掌任務(wù),，翻掌扣掌任務(wù),，拳邊掌任務(wù)對(duì)比，或者運(yùn)動(dòng)順序長(zhǎng)度的變化對(duì)比,。
陳楚僑研究員和他的團(tuán)隊(duì)有針對(duì)性的系統(tǒng)地通過(guò)一篇對(duì)腦功能成像研究的綜述闡述了這一問(wèn)題,。這篇綜述納入了許多涉及不同手指/手部運(yùn)動(dòng)任務(wù)的神經(jīng)基礎(chǔ)的研究，然后使用ALE(Activation Likelihood Estimation)方法做了一個(gè)量化的元分析,。得出結(jié)果是,，當(dāng)單側(cè)運(yùn)動(dòng)任務(wù)以一種簡(jiǎn)單的順序僅僅做手指點(diǎn)擊或者手指/拇指對(duì)點(diǎn)任務(wù)時(shí)，小腦的前部同側(cè)會(huì)被激活,；而小腦的腦室則多數(shù)在手部運(yùn)動(dòng)和手指按鍵任務(wù)中被激活,。該研究進(jìn)一步揭示了小腦不同區(qū)域的激活可能與不同的運(yùn)動(dòng)任務(wù)的要求相聯(lián)系的,。這個(gè)研究是由陳楚僑研究員所負(fù)責(zé)的心理所院重要方向基金項(xiàng)目(KSCX2-YW-R-131)，國(guó)家自然科學(xué)基金(30770723)和973國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃支持的,。（生物谷Bioon.com）
生物谷推薦原始出處：
Brain Research Reviews,，doi:10.1016/j.brainresrev.2008.09.003 ，Raymond C.K. Chan,，Xin Di
Dexterous movement complexity and cerebellar activation: A meta-analysis
Raymond C.K. Chana,b,Jia Huanga, c, d and Xin Dic
aNeuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
bKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
cDepartment of Psychology, Sun Yat-Sen University, Guangzhou, China
dLife Sciences Faculty, Sun Yat-Sen University, Guangzhou, China
The importance of the cerebellum in coordinates of movement has been established by lesion studies. However, there is no clear understanding of whether there is consistent activation in cerebellum across various motor task complexities or how different parts of the cerebellum contribute to finger coordinates in dexterous manipulation. This article reviews imaging studies with data from healthy subjects. A mini meta-analysis using label-based and activation likelihood estimation (ALE) methods reveals that ipsilateral anterior and vermis regions of the cerebellum were consistently activated across various dexterous movement complexities and were associated with finger and hand movement.
