近日，西安電子科技大學(xué)生命科學(xué)技術(shù)學(xué)院神經(jīng)影像研究組秦偉副教授等人與成都中醫(yī)藥大學(xué)等單位合作的一篇有關(guān)功能性消化不良中樞機(jī)制的研究論文,，被Gastroenterology雜志正式接收,，該雜志2010年影響因子12.8，系胃腸疾病行業(yè)內(nèi)世界頂級(jí)期刊,。
據(jù)了解,，功能性消化不良是一種伴有上腹部疼痛、早飽,、惡心嘔吐等癥狀的胃腸道周期性消化系統(tǒng)疾病,，在我國(guó)的發(fā)病率高達(dá)20%。這種疾病雖然不會(huì)威脅人們的生命,，但卻嚴(yán)重影響日常生活質(zhì)量,，對(duì)它的診斷和治療受到了歐美國(guó)家的廣泛關(guān)注。由于其發(fā)病機(jī)理不明,，至今西方醫(yī)學(xué)界沒有找到有效的治療手段,。
生命科學(xué)技術(shù)學(xué)院秦偉等人的論文《Abnormal Resting Brain Activity in Patients with Functional Dyspepsia is Related to Symptom Severity》，通過腦腸互動(dòng)理論揭示了功能性消化不良的中樞機(jī)制,，為臨床治療提供了客觀依據(jù),，指出這種疾病可能是某些抑郁癥的起因，建議及時(shí)治療,，而當(dāng)前最有效的治療手段就是采用中醫(yī)針灸療法,。該論文是近幾年來中醫(yī)界發(fā)表的最高檔次文章。
據(jù)介紹,，我校生命科學(xué)技術(shù)學(xué)院神經(jīng)影像研究組自成立以來,，采用信息技術(shù)等交叉學(xué)科研究手段,，分析探討針刺機(jī)理的相關(guān)問題，近3年來在國(guó)際7種知名刊物共發(fā)表SCI論文23篇,，總影響因子超過60,，2011年榮獲陜西省高校科學(xué)技術(shù)一等獎(jiǎng),。（生物谷Bioon.com）
生物谷推薦原文出處：
Gastroenterology DOI：10.1053/j.gastro.2011.05.003
Fang Zeng, Wei Qin, Fanrong Liang,， Jixin Liu, Yong Tang, Xuguang Liu, Kai Yuan, Shuguang Yu, Wenzhong Song, Mailan Liu, Lei Lan, Xin Gao, Yijun Liu and Jie Tian
Background & Aims
Abnormal processing of visceral sensation at the level of the central nervous system is believed to be involved in functional dyspepsia. However, compared with studies of stimulation-related changes in brain activity, few studies have focused on resting brain activity, which is also important in pathogenesis. We mapped changes in resting brain glucometabolism of patients with functional dyspepsia, compared with healthy subjects, attempted to correlate abnormal brain activity with symptom severity.
Methods
We performed fluorodeoxyglucose (18F) positron emission tomography computed tomography (PET-CT) on 40 patients with functional dyspepsia and 20 healthy subjects who were in resting states. The symptom index of dyspepsia (SID) and Nepean dyspepsia index (NDI) were used to determine symptom severity. The PET-CT data were analyzed using statistical parametric mapping software.
Results
Compared to healthy subjects, patients with functional dyspepsia had higher levels of glycometabolism in the bilateral insula, anterior cingulate cortex (ACC), middle cingulate cortex (MCC), cerebellum, thalamus, prefrontal cortex, precentral gyrus, postcentral gyrus, middle temporal gyrus, superior temporal gyrus, putamen, right parahippocampal gyrus, claustrum, and left precuneus (P<.001). The signal increase in the ACC, insula, thalamus, MCC, and cerebellum was correlated with SID scores and NDI scores (P<.01). The glycometabolism in ACC, insula, thalamus, MCC, and cerebellum of patients with more severe functional dyspepsia were significantly higher than those of patients with less severe functional dyspepsia (P<.005).
Conclusions
In patients with functional dyspepsia, resting cerebral glycometabolism differs significantly from that of healthy subjects. The ACC, insula, thalamus, MCC, and cerebellum might be the key regions that determine the severity of symptoms.
Keywords: brain; neuroimaging; pain; stomach
