北京師范大學(xué)認(rèn)知神經(jīng)科學(xué)與學(xué)習(xí)國家重點實驗室的劉嘉等于2011年07月15日在Journal of Neuroscience上發(fā)表了題為Resting-state neural activity across face-selective cortical regions is behaviorally relevant的文章,。
以往的研究表明,，大腦在靜息狀態(tài)下的自發(fā)神經(jīng)活動并不是隨機(jī)的,，而是在功能相似的腦區(qū)之間存在著較高的相關(guān),。這種相關(guān)性被認(rèn)為反映了腦區(qū)之間受結(jié)構(gòu)連接所調(diào)制的功能關(guān)系,，是近年來認(rèn)知神經(jīng)科學(xué)領(lǐng)域研究的熱點問題,。然而,，盡管大量的研究發(fā)現(xiàn)這種自發(fā)神經(jīng)活動的相關(guān)性廣泛地存在于功能相似的腦區(qū)之間,，我們對這些同步的自發(fā)神經(jīng)活動具有什么功能仍知之甚少,。那么是否這些腦區(qū)間同步的自發(fā)神經(jīng)活動是行為相關(guān)的呢,？抑或他們僅僅只是大腦結(jié)構(gòu)連接的附帶現(xiàn)象？該研究利用核磁共振腦成像技術(shù),，通過直接檢驗兩個面孔加工區(qū)域（FFA和OFA）靜息狀態(tài)下自發(fā)神經(jīng)活動的相關(guān)的程度,，即靜息功能連接強度與行為的相關(guān)，探討了這一問題,。結(jié)果發(fā)現(xiàn)OFA和FFA之間靜息功能連接強度僅與被試在一些面孔加工任務(wù)中的成績相關(guān),，而與非面孔加工任務(wù)的成績無關(guān)，且這種OFA/FFA靜息功能連接的行為相關(guān)性與這兩個腦區(qū)的面孔選擇性和區(qū)域大小無關(guān),。該結(jié)果表明,，面孔的加工不僅依賴于面孔加工區(qū)域各自的功能性，而且依賴于他們之間自發(fā)神經(jīng)活動的同步性,。
該研究為靜息狀態(tài)下腦區(qū)自發(fā)神經(jīng)活動相關(guān)的功能意義提供了強有力的證據(jù),。(生物谷 Bioon.com)
doi:10.1523/?JNEUROSCI.0873-11.2011
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Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant
Qi Zhu, Jiedong Zhang, Yu L. L. Luo, Danie D. Dilks, and Jia Liu
Interest has increased recently in correlations across brain regions in the resting-state fMRI blood oxygen level-dependent (BOLD) response, but little is known about the functional significance of these correlations. Here we directly test the behavioral relevance of the resting-state correlation between two face-selective regions in human brain, the occipital face area (OFA) and the fusiform face area (FFA). We found that the magnitude of the resting-state correlation, henceforth called functional connectivity (FC), between OFA and FFA correlates with an individual's performance on a number of face-processing tasks, not non-face tasks. Further, we found that the behavioral significance of the OFA/FFA FC is independent of the functional activation and the anatomical size of either the OFA or FFA, suggesting that face processing depends not only on the functionality of individual face-selective regions, but also on the synchronized spontaneous neural activity between them. Together, these findings provide strong evidence that the functional correlations in the BOLD response observed at rest reveal functionally significant properties of cortical processing.
