近日，一項發(fā)表在Bipolar Disorder上的研究"Dimensional psychopathology in offspring of parents with bipolar disorder"指出,，與健康父母的孩童相比,，罹患雙相障礙的父母,，其孩童較易出現情感和行為紊亂癥狀。
來自美國匹茲堡大學的Rasim Diler和他的同事們說道：“年輕人罹患雙相障礙,，可增加自殺,、精神病、物質濫用以及發(fā)育和心理社會功能的風險,，且這種疾病的確診時間較晚,，這些患者平均需要10年的時間才能得到確診,，進而進行首次治療。”
本項研究納入年齡6-18歲的兒童,，并分為三組：319例兒童的父母罹患雙相障礙,，但這些兒童無雙相障礙、35例兒童的父母罹患雙相障礙,，且這些兒童亦被診斷為雙相譜系障礙,、235例兒童的父母無雙相障礙（對照組）。
與對照組相比,，雙相障礙患兒及罹患雙相障礙的父母的孩童的多個評估量表（包括兒童行為量表CBCL）的評分明顯增加,。與對照組相比，雙相障礙父母所生的孩子,，較易出現焦慮,、抑郁、注意缺陷,、激越行為等體征,。（生物谷Bioon.com）
相關閱讀：
J Affect Disord：心境穩(wěn)定劑治療延遲或增自殺風險
doi:10.1111/j.1399-5618.2011.00966.x
PMC:
PMID:
Dimensional psychopathology in offspring of parents with bipolar disorder
Rasim Somer Diler1, Boris Birmaher1, David Axelson1, Mihaela Obreja1, Kelly Monk1, Mary Beth Hickey1, Benjamin Goldstein2, Tina Goldstein1, Dara Sakolsky1, Satish Iyengar3, David Brent1, David Kupfer1
Objectives:To compare the dimensional psychopathology in offspring of parents with bipolar disorder (BP) with offspring of community control parents as assessed by the Child Behavior Checklist (CBCL).
Methods:Offspring of parents with BP, who were healthy or had non-BP disorders (any psychiatric disorder other than BP; n = 319) or who had bipolar spectrum disorders (n = 35), and offspring of community controls (n = 235) ages 6–18 years were compared using the CBCL, the CBCL-Dysregulation Profile (CBCL-DP), and a sum of the CBCL items associated with mood lability. The results were adjusted for multiple comparisons and for any significant between-group demographic and clinical differences in both biological parents and offspring.
Results:With few exceptions, several CBCL (e.g., Total, Internalizing, and Aggression Problems), CBCL-DP, and mood lability scores in non-BP offspring of parents with BP were significantly higher than in offspring of control parents. In addition, both groups of offspring showed significantly lower scores in most scales when compared with offspring of parents with BP who had already developed BP. Similar results were obtained when analyzing the rates of subjects with CBCL T-scores that were two standard deviations or higher above the mean.
Conclusions:Even before developing BP, offspring of parents with BP had more severe and higher rates of dimensional psychopathology than offspring of control parents. Prospective follow-up studies in non-BP offspring of parents with BP are warranted to evaluate whether these dimensional profiles are prodromal manifestations of mood or other disorders, and can predict those who are at higher risk to develop BP.
