最近刊登于內(nèi)分泌學(xué)會的《臨床內(nèi)分泌及代謝》J Clin Endocrinol Metab雜志上一項研究"Baseline Sympathetic Nervous System Activity Predicts Dietary Weight Loss in Obese Metabolic Syndrome Subjects"發(fā)現(xiàn)，減肥成功者與減肥抵抗者相比,，前者有顯著較高的神經(jīng)休息活動。
交感神經(jīng)系統(tǒng)廣泛分布于體內(nèi),，下意識里調(diào)控多種生理功能,，包括控制基礎(chǔ)代謝率和飯后卡路里的消耗。本研究調(diào)查了在一組肥胖者熱量飲食干預(yù)計劃中,，交感神經(jīng)系統(tǒng)活動和減肥效果之間的關(guān)系,。
澳大利亞墨爾本貝克心臟與糖尿病研究院的Nora Straznicky博士是這項研究的第一作者，他說：“我們已經(jīng)首次證明,，靜止肌肉交感神經(jīng)活動(MSNA)是一個有效的獨立預(yù)測減肥結(jié)果的指標(biāo),。我們的研究結(jié)果提供兩個機(jī)會。首先,，我們可以識別哪些人對生活方式的干預(yù)措施收益最大,，比如節(jié)食減肥。其次,，通過刺激特定的神經(jīng)活動,，可能有助于減肥治療,。”
參與該試驗的42名超重或肥胖者,，連續(xù)12周每天減少30%的卡路里攝入量,。由微神經(jīng)檢查法測量肌肉交感神經(jīng)活性，即把金屬微電極插進(jìn)神經(jīng)束(束神經(jīng)纖維),。研究人員發(fā)現(xiàn),，靜止肌肉交感神經(jīng)活性基線可以獨立預(yù)測減肥是否成功。
Straznicky說：“我們還發(fā)現(xiàn),，碳水化合物試驗餐后,，減肥成功者神經(jīng)活動大量增加，而減肥抵抗者這些反應(yīng)徹底減弱,。這說明潛意識的神經(jīng)系統(tǒng)活動對于飲食減肥成功具有重要貢獻(xiàn),。”（生物谷bioon.com）
doi:10.1210/jc.2011-2320
PMC:
PMID:
Baseline Sympathetic Nervous System Activity Predicts Dietary Weight Loss in Obese Metabolic Syndrome Subjects
Nora E. Straznicky,Nina Eikelis,Paul J. Nestel,John B. Dixon,Tye Dawood,Mariee T. Grima,Carolina I. Sari,Markus P. Schlaich,Murray D. Esler,Alan J. Tilbrook,Gavin W. Lambert and Elisabeth A. Lambert
Context: The sympathetic nervous system is an important physiological modulator of basal and postprandial energy expenditure.
Objective: Our objective was to investigate whether the variability of weight loss attained during hypocaloric dietary intervention is related to individual differences in baseline sympathetic drive and nutritional sympathetic nervous system responsiveness.
Participants and Methods: Untreated obese subjects (n = 42; body mass index = 32.1 ± 0.5 kg/m2), aged 57 ± 1 yr, who fulfilled Adult Treatment Panel III metabolic syndrome criteria participated in a 12-wk weight loss program using a modified Dietary Approaches to Treat Hypertension (DASH) diet. Muscle sympathetic nerve activity (MSNA) was measured by microneurography at rest and in a subset of subjects during a standard 75-g oral glucose tolerance test.
Results: Weight loss (6.7 ± 0.5 kg) was independently predicted by baseline resting MSNA burst incidence (r = 0.38; P = 0.019), which accounted for 14.3% of the variance after adjustment for age and baseline body weight. Weight loss-resistant subjects in the lower tertile of weight loss (4.4 ± 0.3%) had significantly blunted MSNA responses to oral glucose at baseline compared with successful weight losers (9.6 ± 0.8%). Absolute Δ MSNA averaged −7 ± 2, −6 ± 5, and −3 ± 3 bursts per 100 heartbeats at 30, 60, and 90 min after glucose in the weight loss-resistant group. Corresponding values in the successful weight loss group were 9 ± 3, 12 ± 3, and 15 ± 4 bursts per 100 heartbeats (time × group interaction, P = 0.004).
Conclusions: These findings indicate that baseline sympathetic drive and nutritional sympathetic responsiveness may be important prognostic biological markers for weight loss outcome.
