Neurology發(fā)表了一篇神經(jīng)學(xué)的新研究,，研究指出：日常體力活動(dòng)可能降低各個(gè)年齡階段阿爾茨海默病與認(rèn)知下降的風(fēng)險(xiǎn)。日常體力活動(dòng)主要包括運(yùn)動(dòng),、炒菜,、洗碗、做衛(wèi)生,、打牌及手推輪椅,，這些活動(dòng)低成本、方便、無副作用,，任何年齡的人都能做,，鼓勵(lì)不能參與正式運(yùn)動(dòng)的老人每天進(jìn)行這些活動(dòng)，會(huì)使他們從中受益,，降低患阿爾茨海默病的風(fēng)險(xiǎn),。
該研究有716位老人參與，他們平均年齡82歲,，無癡呆,。為了客觀測定體力活動(dòng)，除記錄參與者的自述外,，在他們不常用的手腕上配置一個(gè)活動(dòng)監(jiān)測儀,，以記錄其日總運(yùn)動(dòng)量與非運(yùn)動(dòng)型體力活動(dòng)量，持續(xù)10天,；研究期間,，每年對(duì)他們進(jìn)行一次認(rèn)知測試，以測量其記憶和思維能力,。結(jié)果是：就阿爾茨海默病發(fā)病可能性來說,，日體力活動(dòng)低于10%的人比日體力活動(dòng)高于10%的要高2.3倍；在緊接著的隨訪中,，71人發(fā)生了阿爾茨海默病,。由此可見，體力活動(dòng)是一個(gè)易變的風(fēng)險(xiǎn)因素,，與認(rèn)知下降和阿爾茨海默病相關(guān)聯(lián),。（生物谷bioon.com）
doi:10.1212/WNL.0b013e3182535d35
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Total daily physical activity and the risk of AD and cognitive decline in older adults
A.S. Buchman, P.A. Boyle, L. Yu, R.C. Shah, R.S. Wilson, and D.A. Bennett
Objective: Studies examining the link between objective measures of total daily physical activity and incident Alzheimer disease (AD) are lacking. We tested the hypothesis that an objective measure of total daily physical activity predicts incident AD and cognitive decline. Methods: Total daily exercise and nonexercise physical activity was measured continuously for up to 10 days with actigraphy (Actical? ; Philips Healthcare, Bend, OR) from 716 older individuals without dementia participating in the Rush Memory and Aging Project, a prospective, observational cohort study. All participants underwent structured annual clinical examination including a battery of 19 cognitive tests. Results: During an average follow-up of about 4 years, 71 subjects developed clinical AD. In a Cox proportional hazards model adjusting for age, sex, and education, total daily physical activity was associated with incident AD (hazard ratio = 0.477; 95% confidence interval 0.273-0.832). The association remained after adjusting for self-report physical, social, and cognitive activities, as well as current level of motor function, depressive symptoms, chronic health conditions, and APOEallele status. In a linear mixed-effect model, the level of total daily physical activity was associated with the rate of global cognitive decline (estimate 0.033, SE 0.012, p= 0.007). Conclusions: A higher level of total daily physical activity is associated with a reduced risk of AD.
