近日，來(lái)自美國(guó)康明斯獸醫(yī)院的研究者研究發(fā)現(xiàn),，如果母親在其青少年時(shí)候長(zhǎng)期使用大麻，則其以后所生的小孩存在更高風(fēng)險(xiǎn)的藥物濫用,。文章中,，研究者研究了長(zhǎng)期暴露于大麻中的青年雌性小鼠的繼代影響。持續(xù)暴露三天之后,，研究者用大麻素受體激動(dòng)劑WIN-55,，212-2對(duì)小鼠進(jìn)行注射（一種和四氫大麻酚具有相同功效的藥物，四氫大麻酚是大麻中的活性成分）,。經(jīng)過(guò)簡(jiǎn)單的處理之后,，小鼠在其成熟之前都不再進(jìn)行任何處理。
研究者使用正常雌性小鼠的雄性后代小鼠作為研究對(duì)照,；相比對(duì)照組,，研究者們發(fā)現(xiàn)在青年期暴露于WIN-55，212-2的小鼠后代更易于選擇含有嗎啡的盒子（morphine-paired chamber）,，結(jié)果揭示了這些小鼠更偏向于選擇阿片劑藥物,。相關(guān)研究成果刊登在了國(guó)際雜志Journal of Psychopharmocology上。
研究者John表示,，我們的研究興趣在于研究是否在青春時(shí)期使用的物質(zhì)會(huì)誘導(dǎo)機(jī)體運(yùn)動(dòng)和神經(jīng)化學(xué)的改變,，進(jìn)而影響后代的發(fā)育。雖然我們使用的模型（嚙齒類(lèi)動(dòng)物）和人類(lèi)的情況不盡相同,，但是結(jié)果揭示了母體藥物的使用,，至少在懷孕之間使用可以影響后代的發(fā)育。另外,，我們需要進(jìn)行深入的研究來(lái)解釋母親青春期藥物的使用和后代孩子影響之間的明確關(guān)系,。
另外也有研究者報(bào)道了，孕婦在懷孕期間暴露于大麻素之中會(huì)影響新生兒的發(fā)育,，會(huì)導(dǎo)致新生兒認(rèn)知能力的損害,，增加新生兒患抑郁和焦慮的風(fēng)險(xiǎn)。（生物谷Bioon.com）
編譯自：Mothers' Teen Cannabinoid Exposure May Increase Response of Offspring to Opiate Drugs
編譯者：T.Shen
doi:10.1177/0269881112443745
PMC:
PMID:
Cannabinoid exposure in adolescent female rats induces transgenerational effects on morphine conditioned place preference in male offspring
John J Byrnes, Nicole L Johnson, Marian E Schenk, Elizabeth M Byrnes
In the United States, marijuana is one of the drugs most abused by adolescents, with females representing a growing number of users. In previous studies, treatment of adolescent female rats with morphine significantly altered brain reward systems in future offspring. As both cannabinoid and opioid systems develop during adolescence, it was hypothesized that early exposure to cannabinoids would induce similar transgenerational effects. In the current study, female rats were treated with the cannabinoid receptor (CB1/CB2) agonist WIN 55,212-2 or its vehicle for three consecutive days during adolescent development (30 days of age), and were subsequently mated in adulthood (60 days of age). The adolescent and adult male offspring of these WIN 55,212-2 (WIN-F1)- or vehicle (VEH-F1)-treated females were tested for their response to morphine using the conditioned place preference (CPP) paradigm. Both adolescent and adult WIN-F1offspring exhibited greater sensitivity to morphine CPP than their VEH-F1 counterparts. Collectively, the findings provide additional evidence of transgenerational effects of adolescent drug use.
