根據(jù)Neurolog最新的一項研究，每天飲酒3次或更多的重度飲酒者患腦出血的風險增加,，他們發(fā)病的年齡比那些不飲酒的患者要早,。
法國里爾大學的研究人員報告，一般來說,，重度飲酒者患腦出血相比其他常見的缺血性卒中,，有更可怕的預后——比不喝酒的患者發(fā)病年齡提前14年。
重度酗酒者最有可能在腦深部發(fā)生卒中,，神經(jīng)病學博士Charlotte Cordonnier和他的同事指出,。60歲以下的患者隨訪2年后，死亡的可能性比其他患者要高,。對于沒有顯著的既往病史的年輕人,，每天喝大量的酒，有助于更嚴重的卒中,。
為了進行分析,，Cordonnier和她的團隊隨訪2004年11月至2009年4月在里爾大學附屬醫(yī)院尋求腦血管治療的患者。該團隊采訪了患者以及患者的親屬,，關于他們的飲酒習慣,。
參與者中，1/4患者是重度飲酒者,，他們卒中的發(fā)病年齡中值是60,，不飲酒的患者患卒中的年齡是74歲。這兩組有類似的并發(fā)癥發(fā)生率,，以及住院時間,。
重度飲酒在以往已被確定為此類卒中的一個危險因素，但研究沒有梳理出遭受不同部位的腦出血患者之間的差異,。
“在這項研究中,，我們選擇的方法突出一個事實，重度飲酒對不同部位的腦出血影響不同”,，研究人員提到,。（生物谷Bioon.com）
doi:10.1212/WNL.0b013e3182698d00
PMC:
PMID:
Heavy alcohol intake and intracerebral hemorrhage: Characteristics and effect on outcome.
Casolla B, Dequatre-Ponchelle N, Rossi C, Hénon H, Leys D, Cordonnier C.
Abstract
OBJECTIVES: To identify associated factors and influence on long-term outcome of heavy alcohol intake in a large prospective cohort of consecutive patients with a spontaneous intracerebral hemorrhage (ICH).
METHODS: Between November 2004 and March 2009, we prospectively recruited 562 consecutive adults with a spontaneous ICH. We excluded patients without information on drinking habit (n = 22). Heavy alcohol intake was defined as a regular consumption of more than 300 g alcohol/week. We performed bivariate and multivariate analyses (logistic regression) based on demographic and radiologic models. Survival analyses were performed using Kaplan-Meier statistics.
RESULTS: Among 540 patients with ICH, 137 (25) were heavy alcohol drinkers (median age 60 vs 74 years in nonabusers; p < 0.0001). In the multivariate demographic model, heavy alcohol drinkers were less likely to be older (odds ratio [OR] 0.97 per 1-year increase, 95% confidence interval [CI] 0.95-0.98) and to have a history of ischemic heart disease (OR 0.34, 95% CI 0.15-0.77) and more likely to be smokers (OR 3.96, 95% CI 2.43-6.46). In the radiologic model, independent factors were nonlobar location of ICH (OR 1.71, 95% CI 1.05-2.77) and less severe leukoaraiosis (OR 0.76 per 1-step increase, 95%CI 0.62-0.73). Platelet counts and prothrombin ratio were significantly lower among heavy alcohol drinkers (respectively, p = 0.01 and p = 0.017). Heavy alcohol intake was predictive of 2 years mortality only among patients younger than 60 years with nonlobar ICH (hazard ratio 1.96, 95% CI 1.06-3.63).
CONCLUSION: Heavy alcohol intake is associated with the occurrence of ICH at a young age. However, the underlying vasculopathy remains unexplored in these patients. Indirect markers suggest small-vessel disease at an early stage that might be enhanced by moderate hemostatic disorders.
