記者日前從中科院昆明動(dòng)物所獲悉，該所研究人員發(fā)現(xiàn),，在歐洲人群中與精神分裂癥顯著相關(guān)的易感位點(diǎn)rs1344706,，在中國(guó)人群中并不是一個(gè)精神分裂癥易感位點(diǎn)。相關(guān)成果在線發(fā)表于《科學(xué)公共圖書(shū)館·綜合》,。
精神分裂癥是困擾人類的重大精神疾病之一，并有非常高的遺傳力,。近年來(lái),，隨著全基因組關(guān)聯(lián)分析的逐步開(kāi)展，全球已報(bào)道了一系列的精神分裂癥易感基因,。然而,，這些研究大多集中在歐洲人群，尚不清楚所報(bào)道的易感基因在亞洲人群中是否也與精神分裂癥顯著相關(guān),。
“ZNF804A基因內(nèi)的單核苷酸多態(tài)位點(diǎn)rs1344706在歐洲人群中與精神分裂癥顯著相關(guān),，這已在獨(dú)立的歐洲群體樣本中得到重復(fù)驗(yàn)證。但是,，在中國(guó)人群中該位點(diǎn)是否與精神分裂癥顯著相關(guān)仍然有爭(zhēng)議,，國(guó)內(nèi)不同的研究小組在各自的樣本中得到了不同的結(jié)果。”博士生李明介紹說(shuō),，他們對(duì)已發(fā)表的中國(guó)人群精神分裂癥病例和對(duì)照樣本（包括8982個(gè)病人和12342個(gè)健康人）進(jìn)行數(shù)據(jù)收集和整合分析,，發(fā)現(xiàn)rs1344706在中國(guó)人群中并不是一個(gè)精神分裂癥易感位點(diǎn)。
相關(guān)專家認(rèn)為,，對(duì)于像精神分裂癥這樣的復(fù)雜疾病,，不同地區(qū)的人群之間由于遺傳背景的差異會(huì)導(dǎo)致關(guān)聯(lián)分析結(jié)果的不同。這提示人們?cè)诰穹至寻Y易感基因的尋找方面需要更加謹(jǐn)慎和小心。（生物谷Bioon.com）
生物谷推薦英文摘要：
plos one doi:10.1371/journal.pone.0065780
Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population
Ming Li equal contributor, Hui Zhang equal contributor, Xiong-jian Luo, Lei Gao, Xue-bin Qi, Pierre-Antoine Gourraud, Bing Su
Recent genetic association studies have implicated several candidate susceptibility variants for schizophrenia among general populations. Rs1344706, an intronic SNP within ZNF804A, was identified as one of the most compelling candidate risk SNPs for schizophrenia in Europeans through genome-wide association studies (GWASs) and replications as well as large-scale meta-analyses. However, in Han Chinese, the results for rs1344706 are inconsistent, and whether rs1344706 is an authentic risk SNP for schizophrenia in Han Chinese is inconclusive. Here, we conducted a systematic meta-analysis of rs1344706 with schizophrenia in Chinese population by combining all available case-control samples (N = 12), including a total of 8,982 cases and 12,342 controls. The results of our meta-analysis were not able to confirm an association of rs1344706 A-allele with schizophrenia (p = 0.10, odds ratio = 1.06, 95% confidence interval = 0.99–1.13). Such absence of association was further confirmed by the non-superiority test (p = 0.0003), suggesting that rs1344706 is not a risk SNP for schizophrenia in Han Chinese. Detailed examinations of individual samples revealed potential sampling bias in previous replication studies in Han Chinese. The absence of rs1344706 association in Han Chinese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating genome-wide association findings of schizophrenia across different ethnic populations.
