B細(xì)胞是一種免疫細(xì)胞,，它的成熟過程對其行使功能來說至關(guān)重要,。研究人員在7月出版的《自然—免疫學(xué)》期刊上報告說,，他們鑒別出一種對B細(xì)胞成熟過程來說至關(guān)重要的蛋白質(zhì)。
B淋巴細(xì)胞產(chǎn)生抗體,，這種抗體分子能給入侵的病原體貼上標(biāo)簽,，從而讓免疫系統(tǒng)向它們發(fā)起進(jìn)攻,。B淋巴細(xì)胞還能改變抗體的類型，讓它們適應(yīng)不同類型的病原體,。
Riccardo Dalla-Favera和同事發(fā)現(xiàn),，如果缺少一種名為 IRF4的分子，B淋巴細(xì)胞就無法轉(zhuǎn)換抗體的類型,。這些結(jié)果表明：IRF4對B淋巴細(xì)胞實(shí)施免疫功能來說至關(guān)重要,。此外，因?yàn)椴糠諦細(xì)胞癌癥患者含有過量的 IRF4,，這些結(jié)果也許有助于研究人員弄清楚為什么會出現(xiàn)某種類型的癌癥,。
原始出處：
Ulf Klein1, Stefano Casola2, Giorgio Cattoretti1, Qiong Shen1, Marie Lia1, Tongwei Mo1, Thomas Ludwig1, Klaus Rajewsky2 & Riccardo Dalla-Favera1. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nature Immunology 7, 773 - 782 (2006)
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作者其它文章：
Selected Publications
Niu, H., Ye, B-H., and Dalla-Favera, R. Antigen-Receptor Signaling Induces MAP Kinase-Mediated Phosphorylation and Degradation of the BCL-6 Transcription Factor. Genes & Dev., 12(13): 1953-1961 (1998).
Pasqualucci, L., Migliazza, A., Fracchiolla N., William C., Neri, A., Baldini, L., Chaganti, R.S.K., Klein, U., Kueppers, R., Rajewsky, K., Dalla-Favera, R. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci (USA), 95: 11816-11821, (1998).
Wu, K.-J., Dalla-Favera, R. Direct activation of telomerase reverse transcriptase (hTERT) gene transcription by c-MYC. Nature Genetics, 21: 220-224 (1999). Wu, K-J., Polack, A., Dalla-Favera, R. (1999).
Wu, K.-J., Polack, A., Dalla-Favera, R. Coordinated regulation of iron-controlling genes, H-Ferritin and IRP2, by c-Myc. Science, 283: 676-679 (1999).
Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RS, Kuppers R, Dalla-Favera R. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature, 19:341-346 (2001).
Klein, U., Tu, Y., Stolovitzky, G.A., Mattioli, M., Cattoretti, G., Husson, H., Freedman, A., Inghirami, G., Cro, L., Baldini, L., Neri, A., Califano, A., Dalla-Favera, R. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogenous phenotype related to memory B cells. J. Exp Med, 97: 2098-2104 (2001) (Supplementary Data)
Klein, U., Gloghini, A., Gaidano, G., Chadburn, A., Cesarman, E., Dalla-Favera, R., Carbone, A. Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts. Blood First Edition Paper, prepublished online January 16, 2003 (Supplementary Data)
Klein, U., Tu, Y., Stolovitzky, G.A., Keller, J.L., Haddad Jr., J., Miljkovic, V., Cattoretti, G., Califano, A., Dalla-Favera, R. Transcriptional Analysis of the B-Cell Germinal Center Reaction. Proc. Acad. Natl. Sci. U. S. A. 100:2639-2644, 2003 (Supplementary Data)
Küppers, R., U. Klein, I. Schwering, V. Distler, A. Bräuninger, G. Cattoretti, Y. Tu, G.A. Stolovitzky, A. Califano, M.-L. Hansmann, and R. Dalla-Favera. Identification of Hodgkin and Reed-Sternberg Cell-Specific Genes by Gene Expression Profiling. J. Clin. Invest. 111:529-537, 2003 (Supplementary Data)
Basso, K., Liso, A., Tiacci, E., Benedetti, R., Pulsoni, A., Foa, R., Di Raimondo, F., Ambrosetti, A., Califano, A., Klein, U., Dalla-Favera, R., Falini, B. Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors. J. Exp. Med. 199 (1): 59-68. (Supplementary Data)
Basso, K., Klein, U., Niu, H., Stolovitzky G.A., Tu, Y., Califano, A., Cattoretti, G., and Dalla-Favera, R. Tracking CD40 signaling during germinal center development Blood 104 (13): 4088-4096 2004. (Supplementary Data)
