導(dǎo)致人類艾滋病的HIV-1病毒具有高度的遺傳變異性，可以突變而躲過(guò)免疫系統(tǒng)的追殺,。而病毒的這種能力使得疫苗的制造變得很困難?，F(xiàn)在David Nickle等人發(fā)表了一種有效的運(yùn)算方法，這種方法可以讓研究人員研發(fā)出能對(duì)付HIV和其它病原的多樣化疫苗,。
這種計(jì)算機(jī)運(yùn)算方法可以藉由刺激對(duì)HIV產(chǎn)生免疫反應(yīng)的分子,，以分析在病毒株中發(fā)現(xiàn)的變異。這些抗原將許多病毒株中發(fā)現(xiàn)的變異,，壓縮到適合疫苗免疫原的基因長(zhǎng)度,。Nike表示，他們已經(jīng)能夠?qū)ef蛋白中發(fā)生的62％的變異和Gag蛋白中81％的變異壓縮成三個(gè)基因長(zhǎng)度的免疫原,。
這些短的免疫原將可用于疫苗研制,，因?yàn)樗鼈兡軌蚍从矵IV-1株中的多樣化特征。這些免疫原應(yīng)該能夠引發(fā)常見(jiàn)病毒株,，以及大部分病毒突變形式造成的免疫反應(yīng),。
（編譯/姜欣慧） (資料來(lái)源 : biocompare)
英文原文：
Vaccine To Cope With Viral Diversity In HIV
4/26/2007
The ability of HIV-1 to develop high levels of genetic diversity and acquire mutations to escape immune pressures contributes to our difficulties in producing a vaccine. David Nickle et al present here an efficient algorithm to develop vaccines that cope with the diversity of HIV or other variable pathogens.
This computational method clarifies and analyzes the variation found in the strains of the virus by describing the molecules which stimulate the immune response to HIV (immunogens) that have multiple forms of variable elements of the virus. These antigens compress the variation found in many viral strains into lengths suitable for vaccine immunogens. "We can capture 62% of the variation found in the Nef protein and 81% of the variation in the Gag protein into immunogens of three gene lengths", says Nickle.
These short-length immunogens are potentially useable in a vaccine, as they reflect the diversity of features in HIV-1 strains. These immunogens should elicit immune responses against high frequency viral strains as well as against most mutant forms of the virus.
