辛辛那提大學(xué)的研究人員證實(shí)了嬰兒暴露于室內(nèi)某些霉菌的組成，有助于建立更強(qiáng)的免疫系統(tǒng),，并保護(hù)他們免于未來(lái)發(fā)生過(guò)敏,。
研究人員發(fā)現(xiàn)暴露于高濃度室內(nèi)霉菌成分：葡聚糖的嬰兒，相較于暴露低濃度的嬰兒,，發(fā)生氣喘的可能性低了三倍,。科學(xué)家相信霉菌是造成成人呼吸癥狀的微小分子,，在地上爬行的嬰兒經(jīng)常暴露于這些分子中,。
這項(xiàng)研究的主要作者和環(huán)境健康科學(xué)家Yulia Iossifova表示，暴露于高濃度的霉菌組成分子中,，可避免嬰兒發(fā)生過(guò)敏,。
只有當(dāng)暴露于高濃度的微生物時(shí)，免疫系統(tǒng)的防護(hù)機(jī)制才會(huì)發(fā)揮效果,。因此太過(guò)干凈的環(huán)境中,，沒有足夠的微生物組成分引起免疫系統(tǒng)反應(yīng)。這項(xiàng)研究結(jié)果發(fā)表于5月號(hào)的Allergy中,。這項(xiàng)流行病學(xué)研究建議,，及早暴露于室內(nèi)霉菌葡聚糖，對(duì)于人類免疫系統(tǒng)具有正面影響,。
（姜欣慧譯） (資料來(lái)源 : biocompare)
英文原文鏈接：
http://news.biocompare.com/newsstory.asp?id=180704
原始出處:
Allergy,，Volume 62 Issue 5 Page 504 - May 2007
To cite this article: Y. Y. Iossifova, T. Reponen, D. I. Bernstein, L. Levin, H. Kalra, P. Campo, M. Villareal, J. Lockey, G. K. K. Hershey, G. LeMasters (2007)
House dust (1-3)-β-d-glucan and wheezing in infants
Allergy 62 (5), 504–513.
doi:10.1111/j.1398-9995.2007.01340.x
House dust (1–3)-β-d-glucan and wheezing in infants
Y. Y. Iossifova11Department of Environmental Health, University of Cincinnati, T. Reponen11Department of Environmental Health, University of Cincinnati, D. I. Bernstein22Division of Allergy-Immunology, Department of Internal Medicine, University of Cincinnati, L. Levin11Department of Environmental Health, University of Cincinnati, H. Kalra22Division of Allergy-Immunology, Department of Internal Medicine, University of Cincinnati, P. Campo22Division of Allergy-Immunology, Department of Internal Medicine, University of Cincinnati, M. Villareal22Division of Allergy-Immunology, Department of Internal Medicine, University of Cincinnati, J. Lockey11Department of Environmental Health, University of Cincinnati, G. K. K. Hershey33Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA, G. LeMasters11Department of Environmental Health, University of Cincinnati
1Department of Environmental Health, University of Cincinnati; 2Division of Allergy-Immunology, Department of Internal Medicine, University of Cincinnati; 3Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Abstract
Background: (1–3)-β-d-glucan is a fungal cell wall component, suspected to cause respiratory symptoms in adults. However, very little is known on the possible health effects of (1–3)-β-d-glucan during infancy. We examined the association between (1–3)-β-d-glucan exposure and the prevalence of allergen sensitization and wheezing during the first year of life in a birth cohort of 574 infants born to atopic parents. Endotoxin exposure was included as a possible confounder.
Methods: (1–3)-β-d-glucan and endotoxin exposures were measured in settled dust collected from infants’ primary activity rooms. The primary outcomes at approximately age one included parental reports of recurrent wheezing and allergen sensitization evaluated by skin prick testing to a panel of 15 aeroallergens as well as milk and egg white.
Results: Exposure to high (1–3)-β-d-glucan concentration (within fourth quartile) was associated with reduced likelihood of both recurrent wheezing [adjusted OR (aOR) = 0.39, 95% CI = 0.16–0.93] and recurrent wheezing combined with allergen sensitization (aOR = 0.13, 95% CI = 0.03–0.61). Similar trends were found between (1–3)-β-d-glucan concentrations and allergen sensitization (aOR = 0.57, 95% CI = 0.30–1.10). In contrast, recurrent wheezing with or without allergen sensitization was positively associated with low (1–3)-β-d-glucan exposure within the first quartile (aOR = 3.04, 95% CI = 1.25–7.38; aOR = 4.89, 95% CI = 1.02–23.57). There were no significant associations between endotoxin exposure and the studied health outcomes.
Conclusions: This is the first study to report that indoor exposure to high levels of (1–3)-β-d-glucan (concentration >60 μg/g) is associated with decreased risk for recurrent wheezing among infants born to atopic parents. This effect was more pronounced in the subgroup of allergen-sensitized infants.
