生物谷：研究人員發(fā)現(xiàn)了免疫細胞的新作用，為免疫系統(tǒng)提供了更好的了解,。免疫細胞對身體炎癥跡象的響應(yīng)很快,。白血細胞（單核白血球）像士兵那樣快速奔赴需要它們的地點，沿著血管的內(nèi)皮進入到組織中與敵人搏斗,。Cedric Auffray和他的法國同事發(fā)現(xiàn),，一群單核白血球在沒有炎癥時潛伏在內(nèi)皮中，它們在毛細管,、靜脈和動脈的表面站崗放哨,，一旦檢測到炎癥或損壞,，它們就成了細胞的緊急反應(yīng)士兵,。這些單核白血球轉(zhuǎn)化為吃掉和消化入侵者的巨噬細胞，直到身體中其它的白血球趕來援助,。在另一項免疫系統(tǒng)的研究中,，Scott N. Mueller和同事發(fā)現(xiàn)，細胞在免疫危機中分泌的“交通警察”小蛋白質(zhì)--趨化因子(chemokines)—在正在進行的免疫響應(yīng)中將自己在淋巴結(jié)的生產(chǎn)減半并且阻礙T細胞的進入,。文章作者得出結(jié)論：這種出乎意料的行為也許增強了淋巴結(jié)環(huán)境產(chǎn)生最優(yōu)免疫響應(yīng)的能力,。
原始出處：
Science 3 August 2007:
Vol. 317. no. 5838, pp. 666 - 670
DOI: 10.1126/science.1142883
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
Cedric Auffray,1 Darin Fogg,1 Meriem Garfa,1 Gaelle Elain,1 Olivier Join-Lambert,2,3 Samer Kayal,1,2,3 Sabine Sarnacki,2,3 Ana Cumano,4 Gregoire Lauvau,5 Frederic Geissmann1,2,3*
The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX3CR1 and was required for rapid tissue invasion at the site of an infection by this "resident" monocyte population, which initiated an early immune response and differentiated into macrophages.
1 Institut Nationale de la Santé et de la Recherche Médicale (INSERM) U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Fédératif de Recherche Necker-Enfants Malades, Paris, France.
2 University Paris-Descartes, Paris, France.
3 Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
4 INSERM U668, Unité de Développement des Lymphocytes, Institut Pasteur, Paris, France.
5 INSERM E03-44, Institut de Pharmacologie Moleculaire et Cellulaire, Nice, France.
* To whom correspondence should be addressed. E-mail: [email protected]
