多發(fā)性硬化癥(MS)是一種自身免疫性疾病,。當(dāng)身體里的T細(xì)胞攻擊用來(lái)隔絕大腦、脊髓和視神經(jīng)的神經(jīng)纖維多脂肪髓鞘時(shí),，就會(huì)產(chǎn)生多發(fā)性硬化癥,，因?yàn)槿狈ΡＷo(hù)層的神經(jīng)無(wú)法在體內(nèi)傳送電子信號(hào)。這一疾病可以在人體內(nèi)維持?jǐn)?shù)十年,，逐步摧毀中樞神經(jīng)系統(tǒng),。Joel Stern領(lǐng)導(dǎo)的研究小組培育出了可以在小鼠體內(nèi)抑制多發(fā)性自身免疫性疾病、包括多發(fā)性硬化癥的調(diào)節(jié)性T細(xì)胞,。相關(guān)論文發(fā)表在美國(guó)《國(guó)家科學(xué)院院刊》（PNAS）上,。
為了培育出可以對(duì)抗多發(fā)性硬化癥的T細(xì)胞，研究人員先用被稱為氨基酸共聚物的化合物對(duì)小鼠進(jìn)行免疫,，再?gòu)乃鼈兊钠⒑土馨徒Y(jié)中培育出T細(xì)胞。這些新的T細(xì)胞系分泌出高水平的IL-10和IL-13,，兩者均為免疫化合物,，在免疫抑制中扮演重要的角色。當(dāng)這些分泌IL-10的T細(xì)胞被轉(zhuǎn)移到被誘發(fā)了包括多發(fā)性硬化癥在內(nèi)的自身免疫性疾病的小鼠身上時(shí),，它們表現(xiàn)出了可以預(yù)防或減輕這類疾病的功能。（來(lái)源：EurekAlert!中文版）
生物谷推薦原始出處：
（PNAS）,，doi：10.1073/pnas.0712131105，Joel N. H. Stern,，Jack L. Strominger
Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice
Joel N. H. Stern, Derin B. Keskin, Hong Zhang, HuiJuan Lv, Zenichiro Kato, and Jack L. Strominger
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
Contributed by Jack L. Strominger, December 26, 2007 (sent for review November 19, 2007)
Abstract
IL-10-secreting regulatory T cell lines specific to glatiramer acetate [poly(Y,E,A,K)n] or poly(Y,F,A,K)n have been established from the enlarged spleen and lymph nodes that result from copolymer treatment of SJL mice in which experimental autoimmune encephalomyelitis was induced by PLP139-151. These CD4+CD25+T cell lines secrete high levels of IL-10 and IL-13 but only small amounts of IL-4 and virtually no TGF-β, IL-17, IL-6, IFN-, or TNF-. Their phenotypes are particularly characterized by the absence of Foxp3 and the presence of two TNFR family members, CD30 and GITR. The lines proliferated specifically to the immunizing copolymers but were autoantigen-nonspecific, in that the same T cell line could suppress autoimmunity induced by three different autoantigens in SJL mice, i.e., PLP139-151(EAE), MBP85-99 (EAE), and bovine peripheral nerve myelin (experimental autoimmune neuritis), indicating they function by bystander suppression.
