宿主對微生物分子的瞬時(shí)耐受性會帶來許多感染性疾病,，一般人們認(rèn)為這種耐受性可以減少炎癥引起的損傷，但實(shí)際上這種耐受性會改變宿主的防御功能,。
Lu等人在9月11日的《細(xì)胞—宿主與微生物》（Cell Host & Microbe）雜志上報(bào)道了他們的發(fā)現(xiàn)：在缺乏脂?；饷福ˋOAH）的小鼠體內(nèi)，革蘭氏陰性菌誘導(dǎo)的耐受性的恢復(fù)被大大推遲,，AOAH具有部分去除細(xì)菌細(xì)胞壁脂多糖（LPS）的?；饔谩６吧偷男∈笤诟骨蛔⑸渲嗵腔蚋锾m陰性菌后可以在14天內(nèi)恢復(fù)正常的反應(yīng),，AOAH缺陷型小鼠則會大大降低前炎癥反應(yīng),，至少需要3周時(shí)間才能恢復(fù)注射脂多糖后的正常反應(yīng)。與此相反,，脂多糖引物-Aoah敲除的小鼠保持著的抗炎反應(yīng),，這一點(diǎn)可從白細(xì)胞介素-10的血漿水平獲知。脂多糖引物-Aoah敲除的小鼠經(jīng)受了較長的耐受期,，且對大腸桿菌高度敏感,。
因此,，滅活的脂多糖作為微生物的刺激免疫分子，對于恢復(fù)感染革蘭陰性細(xì)菌動物的防御功能具有重要作用,。（生物谷Bioon.com）
生物谷推薦原始出處：
Cell Host & Microbe,，Vol 4, 293-302, 11 September 2008，Mingfang Lu, Robert S. Munford
Host Inactivation of Bacterial Lipopolysaccharide Prevents Prolonged Tolerance Following Gram-Negative Bacterial Infection
Mingfang Lu,1, Alan W. Varley,1 Shoichiro Ohta,2 John Hardwick,1 and Robert S. Munford1,
1 Infectious Disease Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9113, USA
2 Department of Laboratory Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, Saga 849-8501, Japan
A transient state of tolerance to microbial molecules accompanies many infectious diseases. Such tolerance is thought to minimize inflammation-induced injury, but it may also alter host defenses. Here we report that recovery from the tolerant state induced by Gram-negative bacteria is greatly delayed in mice that lack acyloxyacyl hydrolase (AOAH), a lipase that partially deacylates the bacterial cell-wall lipopolysaccharide (LPS). Whereas wild-type mice regained normal responsiveness within 14 days after they received an intraperitoneal injection of LPS or Gram-negative bacteria, AOAH-deficient mice had greatly reduced proinflammatory responses to a second LPS injection for at least 3 weeks. In contrast, LPS-primed Aoah- knockout mice maintained an anti-inflammatory response, evident from their plasma levels of interleukin-10 (IL-10). LPS-primed Aoah-knockout mice experiencing prolonged tolerance were highly susceptible to virulent E. coli challenge. Inactivating LPS, an immunostimulatory microbial molecule, is thus important for restoring effective host defenses following Gram-negative bacterial infection in animals.
