綜合利用了流行病學(xué),、心理學(xué)和博弈論，Sanjay Basu及其同事開發(fā)了一個(gè)計(jì)算機(jī)模型，用于研究公眾認(rèn)知和經(jīng)濟(jì)情況對人類乳頭瘤病毒（HPV）疫苗接種的影響,。
這組科學(xué)家利用了對美國的適合接種疫苗的兒童的父母的調(diào)查數(shù)據(jù),，結(jié)果發(fā)現(xiàn)目前對于HPV疫苗接種的認(rèn)知和經(jīng)濟(jì)因素都可能阻止了免疫接種水平足以達(dá)到讓群體的健康效果最大化并讓與HPV疾病有關(guān)的健康開支最小化的程度。HPV疫苗可能有潛力減少宮頸癌病例,，但是對該疫苗的質(zhì)疑仍然存在,，諸如它的副作用及費(fèi)用。這組作者利用博弈論模擬了人類在關(guān)鍵情況下的行為,，從而審視了與美國公眾對HPV免疫接種計(jì)劃可能的接受程度有關(guān)的因素,，并證明了為了實(shí)現(xiàn)一個(gè)成功的免疫接種策略，科學(xué)家和決策者可能需要首先消除家長認(rèn)為青少年性行為增加的擔(dān)憂,。這組作者說,，考慮到和看病以及接受疫苗接種有關(guān)的成本，經(jīng)濟(jì)成本也造成了一個(gè)社會學(xué)的障礙,。（生物谷Bioon.com）
生物谷推薦原始出處：
PNAS published online before print November 17, 2008, doi:10.1073/pnas.0808114105
Integrating epidemiology, psychology, and economics to achieve HPV vaccination targets
Sanjay Basu, Gretchen B. Chapman, and Alison P. Galvani
Human papillomavirus (HPV) vaccines provide an opportunity to reduce the incidence of cervical cancer. Optimization of cervical cancer prevention programs requires anticipation of the degree to which the public will adhere to vaccination recommendations. To compare vaccination levels driven by public perceptions with levels that are optimal for maximizing the community's overall utility, we develop an epidemiological game-theoretic model of HPV vaccination. The model is parameterized with survey data on actual perceptions regarding cervical cancer, genital warts, and HPV vaccination collected from parents of vaccine-eligible children in the United States. The results suggest that perceptions of survey respondents generate vaccination levels far lower than those that maximize overall health-related utility for the population. Vaccination goals may be achieved by addressing concerns about vaccine risk, particularly those related to sexual activity among adolescent vaccine recipients. In addition, cost subsidizations and shifts in federal coverage plans may compensate for perceived and real costs of HPV vaccination to achieve public health vaccination targets.
