哈佛大學(xué)醫(yī)學(xué)院免疫疾病研究所的科學(xué)家Klaus Rajewsky教授在最新一期的Cell雜志發(fā)表綜述文章,，對(duì)microRNA控制免疫系統(tǒng)的基本原則問題進(jìn)行了歸納總結(jié)。
對(duì)microRNA的調(diào)控研究發(fā)現(xiàn),，microRNA（miRNA）對(duì)哺乳動(dòng)物免疫系統(tǒng)具有重要的調(diào)控意義,。研究者發(fā)現(xiàn)用遺傳技術(shù)敲除某一miRNA或是消減某一miRNA基因的功能（與免疫功能相關(guān)的miRNA），對(duì)免疫系統(tǒng)的發(fā)育會(huì)造成重大的破壞作用,，導(dǎo)致機(jī)體發(fā)生疾病,，比如說，可能引發(fā)自體免疫疾病甚至是癌癥,。盡管,，單個(gè)的miRNA就能調(diào)節(jié)上百個(gè)靶位基因影響蛋白表達(dá)，一旦影響蛋白的表達(dá)就會(huì)對(duì)生物體的正常生理功能造成影響,，也許某些關(guān)鍵蛋白表達(dá)量的降低會(huì)招來惡果,，導(dǎo)致細(xì)胞功能異常，甚至產(chǎn)生疾病,。（生物谷Bioon.com）
生物谷推薦原始出處：
Cell,9 January 2009 doi:10.1016/j.cell.2008.12.027
MicroRNA Control in the Immune System: Basic Principles
Changchun Xiao1,2andKlaus Rajewsky1,,
1 Immune Disease Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
2 Present address: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
MicroRNA (miRNA) control has emerged as a critical regulatory principle in the mammalian immune system. Genetic ablation of the miRNA machinery, as well as loss or deregulation of certain individual miRNAs, severely compromises immune development and response and can lead to immune disorders like autoimmunity and cancer. Although individual miRNAs modulate protein output from hundreds of target genes, they may impact physiological processes by regulating the concentrations of just a few key cellular proteins that may be components of a single or of functionally interrelated pathways in a given cellular context.
