本次發(fā)表的《科學(xué)》文章主要解釋了Bcl6轉(zhuǎn)錄因子對輔助T細(xì)胞生長發(fā)育的調(diào)控作用。
CD4+輔助T細(xì)胞的一個(gè)基本功能是調(diào)節(jié)B細(xì)胞介導(dǎo)的體液免疫,。濾泡輔助性T細(xì)胞（T follicular helper ,，Tfh）通過細(xì)胞因子白介素-6和白介素-21來調(diào)節(jié)B細(xì)胞的功能。在Tfh發(fā)揮調(diào)節(jié)功能的過程中,，Bcl6轉(zhuǎn)錄因子發(fā)揮了重要的作用,。
Bcl6轉(zhuǎn)錄因子的表達(dá)受白介素-6和白介素-21的調(diào)控，Bcl6過度表達(dá)可誘導(dǎo)Tfh相關(guān)的基因表達(dá)并抑制其他類型的輔助性T細(xì)胞的分化。如果Bcl6缺陷則導(dǎo)致Tfh發(fā)育異常,，并破壞生發(fā)中心的免疫應(yīng)答,，改變其他效應(yīng)T細(xì)胞的表達(dá)量,。
這些研究結(jié)果表明,，Bcl6是Tfh細(xì)胞發(fā)育過程中必不可少的調(diào)節(jié)因子,。（生物谷Bioon.com）
生物谷推薦原始出處：
Science DOI: 10.1126/science.1176676
Bcl6 Mediates the Development of T Follicular Helper Cells
Roza I. Nurieva 1*, Yeonseok Chung 1, Gustavo J. Martinez 1, Xuexian O. Yang 1, Shinya Tanaka 1, Tatyana D. Matskevitch 1, Yi-Hong Wang 1, Chen Dong 1*
1 Department of Immunology, M. D. Anderson Cancer Center, Houston, TX 77030, USA.
A fundamental function of CD4+ helper T (Th) cells is the regulation of B cell–mediated humoral immunity. Development of T follicular helper (Tfh) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21, but is independent of Th1, Th2, and Th17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expressed in Tfh cells. Bcl6 expression is regulated by interleukin-6 and interleukin-21. Bcl6 overexpression induced Tfh-related gene expression and inhibited other Th lineage cell differentiation in a DNA binding–dependent manner. Moreover, Bcl6 deficiency in T cells resulted in impaired Tfh cell development, and germinal center reactions, and altered production of other effector T cells subsets. Our data thus illustrate that Bcl6 is required for programming of Tfh cell generation.
