新一期英國《自然－免疫學(xué)》雜志刊登報告說，維生素D不僅是身體生長發(fā)育所必需的,，在免疫方面也發(fā)揮著重要作用,，它是免疫細胞T細胞對異物發(fā)動攻擊的“司令員”,。

丹麥哥本哈根大學(xué)研究人員報告說,，免疫系統(tǒng)中的T細胞具有識別并攻擊細菌和病毒等異物的功能,，但它平時并不處于“戰(zhàn)斗狀態(tài)”，需要得到一個“攻擊信號”才能完成從不活躍狀態(tài)到活躍狀態(tài)的轉(zhuǎn)換,。維生素D就在這個過程中扮演了“司令員”的角色,。這次的研究發(fā)現(xiàn)，如果沒有維生素D,，T細胞就算探測到異物也不會采取行動,，依然處于不活躍狀態(tài)。

研究人員說,，這一發(fā)現(xiàn)說明,，可以通過調(diào)節(jié)體內(nèi)維生素D含量來控制免疫反應(yīng)。比如,，免疫功能弱的人可以通過補充維生素D來增強抗病能力,；而在進行器官移植等手術(shù)后，則可以通過減少體內(nèi)維生素D含量,，來減少排異反應(yīng),。

維生素D存在于魚類、雞蛋等天然食物中,，多曬太陽也有助于人體合成維生素D,。維生素D通過調(diào)節(jié)體內(nèi)鈣、磷等元素的代謝來維持骨骼,、牙齒的正常生長發(fā)育,。（生物谷Bioon.com）

維生素D與健康：

AJCN：維生素D對人體作用大于現(xiàn)有估計

RCCM：維生素D或可緩解哮喘癥狀

Annals of Epidemiology：補充維生素D可預(yù)防前列腺癌

J. Clin. End. Metab.：缺乏維生素D易導(dǎo)致婦女肥胖

The Lancet Oncology：牙周疾病可能導(dǎo)致胰腺癌

Arch Gen Psychiatry.：缺乏VD可引發(fā)抑郁癥

JAMA：服用維生素可能對人體造成傷害

生物谷推薦原始出處：

Nature Immunology 7 March 2010 | doi:10.1038/ni.1851

Vitamin D controls T cell antigen receptor signaling and activation of human T cells

Marina Rode von Essen1, Martin Kongsbak1, Peter Schjerling2,4, Klaus Olgaard5, Niels ?dum1,3 & Carsten Geisler1

Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-γ1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of ~75-fold in PLC-γ1 expression, which correlated with greater TCR responsiveness. Induction of PLC-γ1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-γ1, which are required for subsequent classical TCR signaling and T cell activation.

1 Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
2 Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
3 Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
4 Institute of Sports Medicine, Bispebjerg Hospital, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Denmark.
5 Department of Nephrology, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Denmark.