美國紐約西奈山醫(yī)學(xué)院的Scott H. Sicherer博士及其同事研究發(fā)現(xiàn)，百白破疫苗中可能殘留的酪蛋白可導(dǎo)致嚴(yán)重牛奶過敏患兒發(fā)生疫苗過敏反應(yīng),，不過多數(shù)牛奶過敏患兒接種百白破疫苗仍是安全的,。該研究發(fā)表在《過敏和臨床免疫雜志》5月30日在線版上(J Allergy Clin Immunol 2011 doi: 10.1016/j.jaci.2011.04.046)。
研究者檢索全美疫苗不良事件報(bào)告系統(tǒng)的數(shù)據(jù)后發(fā)現(xiàn),，2007~2010年共報(bào)告了39例針對無細(xì)胞百白破疫苗(DTaP),、百白破疫苗(DTP)或減量破傷風(fēng)白喉非細(xì)胞性百日咳混合疫苗(Tdap)的過敏反應(yīng)。其中8例患兒在接種上述疫苗的加強(qiáng)針之后1 h內(nèi)出現(xiàn)過敏癥狀。
為了確定疫苗中來自牛奶的殘留酪蛋白是否與疫苗過敏反應(yīng)有關(guān),，研究者分析了上述8例患兒的臨床資料,。結(jié)果顯示，其中6例患兒既往曾發(fā)生急性牛奶過敏反應(yīng),，其余2例患兒則依據(jù)血清學(xué)檢查結(jié)果被診斷為牛奶過敏,。在發(fā)生疫苗過敏反應(yīng)后2年內(nèi)，這8例患兒的牛奶特異性IgE水平均增高,。
研究者還對Tdap和DTaP疫苗進(jìn)行了檢測,，發(fā)現(xiàn)8個(gè)批次的疫苗中含有微量酪蛋白，因此推測殘留酪蛋白可能導(dǎo)致高敏兒童發(fā)生疫苗過敏反應(yīng),。
但鑒于百白破疫苗的過敏反應(yīng)十分罕見,，研究者認(rèn)為多數(shù)高敏兒童仍可以耐受含有殘留酪蛋白的疫苗，即接種該疫苗仍是安全的,。（生物谷Bioon.com）
生物谷推薦原文出處：
The Journal of Allergy and Clinical Immunology doi:10.1016/j.jaci.2011.04.046
Anaphylaxis to diphtheria, tetanus, and pertussis vaccines among children with cow’s milk allergy
Jacob D. Kattan, MD, George N. Konstantinou, MD, PhD, MSc, Amanda L. Cox, MD, Anna Nowak-Wgrzyn, MD, Gustavo Gimenez, BA, Hugh A. Sampson, MD, Scott H. Sicherer, MD
Disclosure of potential conflict of interest: H. A. Sampson is a consultant for Allertein Therapeutics, LLC; has received research support from the Food Allergy Initiative and the National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH); is a consultant and scientific advisor for the Food Allergy Initiative; is a medical advisor for the Food Allergy & Anaphylaxis Network; is a scientific advisor for the University of Nebraska–FARRP; and is 45% owner of Herbal Springs, LLC. S. H. Sicherer is a consultant for the Food Allergy Initiative and has received research support from the NIAID/NIH. The rest of the authors have declared that they have no conflict of interest.
