近日，受國際著名雜志Cell Press的Trends in Immunology雜志邀請,，中國科學(xué)院上海生命科學(xué)研究院/上海交通大學(xué)醫(yī)學(xué)院健康科學(xué)研究所時玉舫研究員領(lǐng)導(dǎo)的免疫與組織干細(xì)胞研究組于2012年1月在線發(fā)表了題為“How mesenchymal stem cells interact with tissue immune responses”的研究綜述文章,。
該綜述基于近年來時玉舫研究組對于間充質(zhì)干細(xì)胞免疫學(xué)的主要研究成果和該領(lǐng)域的最新進(jìn)展,，系統(tǒng)闡述了間充質(zhì)干細(xì)胞與免疫系統(tǒng)的相互作用及其機(jī)制,，疾病發(fā)生過程中的作用，并對創(chuàng)傷愈合的影響以及其在臨床應(yīng)用中的廣闊前景,，提出了此領(lǐng)域內(nèi)亟需解答的關(guān)鍵問題,。
間充質(zhì)干細(xì)胞(mesenchymal stem cells，MSCs)是骨髓中除造血干細(xì)胞以外的一種組織干細(xì)胞,，廣泛分布于骨髓,、肝臟、脂肪,、臍帶等多種組織中,，具有強(qiáng)大的自我更新能力和多向分化潛能。因此,，間充質(zhì)干細(xì)胞移植在再生醫(yī)學(xué)領(lǐng)域具有廣闊的應(yīng)用前景,。同時,，作為一種重要的免疫調(diào)節(jié)細(xì)胞，MSCs在炎癥細(xì)胞因子刺激后對免疫系統(tǒng)表現(xiàn)出很強(qiáng)的調(diào)節(jié)作用,，所以MSCs有望應(yīng)用于治療系統(tǒng)性紅斑狼瘡等自身免疫疾病,。在時玉舫研究員的帶領(lǐng)下，該研究組科研人員對間充質(zhì)干細(xì)胞與免疫系統(tǒng)的相互作用進(jìn)行了系統(tǒng)的研究工作,，闡明了間充質(zhì)干細(xì)胞對于免疫系統(tǒng)具體的調(diào)節(jié)機(jī)制,，極大地豐富了人們對于間充質(zhì)干細(xì)胞的理解，在該研究領(lǐng)域成果顯著,，受到了國際同行的廣泛關(guān)注,。（生物谷Bioon.com）
doi:10.1016/j.it.2011.11.004
PMC:
PMID:
How mesenchymal stem cells interact with tissue immune responses
Yufang Shi, Juanjuan Su, Arthur I. Roberts, Peishun Shou, Arnold B. Rabson, Guangwen Ren
Mesenchymal stem cells (MSCs), also called multipotent mesenchymal stromal cells, exist in almost all tissues and are a key cell source for tissue repair and regeneration. Under pathological conditions, such as tissue injury, these cells are mobilized towards the site of damage. Tissue damage is usually accompanied by proinflammatory factors, produced by both innate and adaptive immune responses, to which MSCs are known to respond. Indeed, recent studies have shown that there are bidirectional interactions between MSCs and inflammatory cells, which determine the outcome of MSC-mediated tissue repair processes. Although many details of these interactions remain to be elucidated, we provide here a synthesis of the current status of this newly emerging and rapidly advancing field.
