荷蘭的一項研究顯示,引起2003-04年度亞洲禽流感爆發(fā)的病毒能感染貓,。Thijs Kuiken和文章合作者指出,,這些發(fā)現(xiàn)出人意料,因為家貓通常被認為是不受此類A流感病毒感染的,。這個禽流感A病毒名為H5N1,,因為它,,亞洲的8個國家屠宰了大批的家禽,這個病毒也感染了人類,,而且許多被感染者因此喪生,。在禽流感爆發(fā)期間,有一些貓也被感染的道聽途說,,因此Kuiken和同事對當貓通過呼吸道接觸這個病毒或通過吃被感染的雞后是否生病做了研究,。六只貓得了嚴重的肺病,,而且將病傳染給另外兩只與它們在一起生活的貓,。研究人員還在貓身上測試了另一種流感病毒H3N2,這個病毒導(dǎo)致最常見的人類流感,。用類似方式接觸個病毒的貓沒有生病,。作者說,他們的發(fā)現(xiàn)指出,,在H5N1爆發(fā)期間,,貓也面臨被感染的危險,而且可能在農(nóng)場家禽中傳播病毒起作用,,貓也可能成為人類感染的潛在病源,。
Avian H5N1 Influenza in Cats
During the 2003-2004 outbreak of avian influenza A (H5N1) virus in Asia, there were anecdotal reports of fatal infection in domestic cats, although this species is considered resistant to influenza. We experimentally inoculated cats with H5N1 virus intratracheally and by feeding virus-infected chickens. The cats excreted virus, developed severe diffuse alveolar damage, and transmitted virus to sentinel cats. These results show that domestic cats are at risk of disease or death from H5N1 virus, can be infected by horizontal transmission, and may play a role in the epidemiology of this virus.