生物谷報道:最近美國科學家發(fā)現(xiàn)了一種全新的,,可能致命的細菌,,這在之前從未被發(fā)現(xiàn)過,。
細菌是在一位43歲的美國婦女體內(nèi)發(fā)現(xiàn)的,,她在秘魯進行了為期3周的旅行,結(jié)果患上了類似傷寒或瘧疾的疾病,。該婦女最后痊愈了,。
這種細菌被稱為Bartonella rochalimae,它和一次世界大戰(zhàn)中造成成千上萬軍人感染軍壕熱的細菌很類似,,軍壕熱通過虱子傳播,。而之前對于和AIDS相關(guān)的由貓抓引起的疾病的研究幫助加州大學San Francisco分校(UCSF)和美國疾病控制中心的專家成功分離出了這一細菌。
以上結(jié)果發(fā)表在the New England Journal of Medicine上,。
從秘魯回到美國兩周之后,,患者經(jīng)受了致命的貧血、皮疹,、脾臟腫大,、失眠及持續(xù)數(shù)周的高熱癥狀。但和她一同旅行的同伴并未表現(xiàn)出相同的癥狀,。
在秘魯?shù)陌驳谒股矫}存在一種類似的細菌,,它由沙蠅傳播,專家起初認為這是造成疾病的原因,。但進一步的分析表明病因是其它細菌,。
文章主要作者,來自UCSF的Jane Koehler博士表示,,這是發(fā)現(xiàn)的第6種能感染人類的這類細菌,。1987年Koehler在舊金山綜合醫(yī)院診斷了第一位感染了Bartonella細菌的病人,而在1997年,,她的小組發(fā)現(xiàn)這一細菌能造成貓抓疾病,。其癥狀包括淋巴結(jié)腫大以及發(fā)燒等。
這一新發(fā)現(xiàn)的細菌能通過利用針對貓抓病的不同的抗生素得到治療,。Koehler說:“當一個病人持續(xù)高熱時,我們需要迅速做出正確診斷和治療,,特別是對那些免疫系統(tǒng)很弱的人,。” (引自教育部科技發(fā)展中心)
英文原文鏈接:http://www.physorg.com/news100450677.html
physorg.com
原始出處:
the New England Journal of Medicine Volume 356:2381-2387 June 7, 2007 Number 23
Bacteremia, Fever, and Splenomegaly Caused by a Newly Recognized Bartonella Species
Marina E. Eremeeva, M.D., Ph.D., Helen L. Gerns, B.A., Shari L. Lydy, Ph.D., Jeanna S. Goo, B.S., Edward T. Ryan, M.D., Smitha S. Mathew, B.S., Mary Jane Ferraro, Ph.D., Judith M. Holden, M.P.H., William L. Nicholson, Ph.D., Gregory A. Dasch, Ph.D., and Jane E. Koehler, M.D.
SUMMARY
Bartonella species cause serious human infections globally, including bacillary angiomatosis, Oroya fever, trench fever, and endocarditis. We describe a patient who had fever and splenomegaly after traveling to Peru and also had bacteremia from an organism that resembled Bartonella bacilliformis, the causative agent of Oroya fever, which is endemic to Peru. However, genetic analyses revealed that this fastidious bacterium represented a previously uncultured and unnamed bartonella species, closely related to B. clarridgeiae and more distantly related to B. bacilliformis. We characterized this isolate, including its ability to cause fever and sustained bacteremia in a rhesus macaque. The route of infection and burden of human disease associated with this newly described pathogen are currently unknown.