美國Brookhaven國家實(shí)驗(yàn)室,、愛爾蘭科克大學(xué)和奧地利Graz技術(shù)大學(xué)的科學(xué)家發(fā)現(xiàn),，植物中常見的一種細(xì)菌和某種住院患者機(jī)會(huì)性感染相關(guān)細(xì)菌之間存在極大的相似之處?？茖W(xué)家稱這一發(fā)現(xiàn)對生物技術(shù)具有重要影響,，因?yàn)檫@種植物細(xì)菌在一系列生物技術(shù)中被應(yīng)用,。
Daniel van der Lelie及其同事對兩種Stenotrophomonas maltophilia細(xì)菌進(jìn)行了對比,。Stenotrophomonas細(xì)菌具有多種功能,，并且能適應(yīng)不同的環(huán)境,。某些菌種能導(dǎo)致血液和肺部感染，而另一些則能促進(jìn)植物生長,。研究人員鑒定出能使兩種細(xì)菌對諸多抗生素產(chǎn)生抗性的基因。據(jù)van der Lelie稱,，這表明抗生素抗性是該類細(xì)菌核基因組的一部分,，而并非醫(yī)院中那種細(xì)菌的特有性狀。他警告說,，盡管Stenotrophomonas已經(jīng)表現(xiàn)了一定的潛力,，比如促進(jìn)植物生長、保護(hù)植物免受病原體侵襲以及生產(chǎn)蛋白藥物和酶等,，但在生物技術(shù)中需謹(jǐn)慎應(yīng)用這種細(xì)菌,。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Reviews Microbiology 7, 514-525 (July 2009) | doi:10.1038/nrmicro2163
The versatility and adaptation of bacteria from the genus Stenotrophomonas
Robert P. Ryan1, Sebastien Monchy2, Massimiliano Cardinale3, Safiyh Taghavi2, Lisa Crossman4, Matthew B. Avison5, Gabriele Berg3, Daniel van der Lelie2 & J. Maxwell Dow2
The genus Stenotrophomonas comprises at least eight species. These bacteria are found throughout the environment, particularly in close association with plants. Strains of the most predominant species, Stenotrophomonas maltophilia, have an extraordinary range of activities that include beneficial effects for plant growth and health, the breakdown of natural and man-made pollutants that are central to bioremediation and phytoremediation strategies and the production of biomolecules of economic value, as well as detrimental effects, such as multidrug resistance, in human pathogenic strains. Here, we discuss the versatility of the bacteria in the genus Stenotrophomonas and the insight that comparative genomic analysis of clinical and endophytic isolates of S. maltophilia has brought to our understanding of the adaptation of this genus to various niches.
1 BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, University College Cork, Cork, Ireland.
2 Brookhaven National Laboratory, Biology Department, Upton, New York 11973-5000, USA.
3 Institute for Environmental Biotechnology, Graz University of Technology, Graz, Austria.
4 Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
5 Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK.
