美國(guó)羅得島州醫(yī)院的一項(xiàng)新研究發(fā)現(xiàn),,耐甲氧苯青霉素金黃色葡萄球菌(MRSA)的感染有顯著的季節(jié)特征,感染率在夏季和秋季尤為顯著,。而在人群差異方面,與成人相比,這種病菌更易感染兒童,。相關(guān)研究已發(fā)表于《公共科學(xué)圖書(shū)館—綜合》(PLoS ONE)雜志網(wǎng)絡(luò)版。
論文第一作者、羅得島州醫(yī)院流行病學(xué)與感染控制科主任倫納德·麥摩爾和他的同事在其微生物學(xué)實(shí)驗(yàn)室中對(duì)MRSA毒株進(jìn)行了10年的研究,。結(jié)果發(fā)現(xiàn),,就兒童而言,他們?cè)谙那锛竟?jié)更易感染MRSA,,與冬季和春季相比,,兒童社區(qū)獲得感染(CA)數(shù)量和住院獲得感染(HA)數(shù)量要分別高出大約1.85倍和2.94倍。對(duì)于成人來(lái)說(shuō),,夏秋季節(jié)通過(guò)社區(qū)感染途徑感染MRSA的數(shù)量也要高出1.14倍,,但在住院感染途徑上,季節(jié)變化對(duì)數(shù)據(jù)的影響并不明顯,。
為進(jìn)一步證實(shí)這一結(jié)論,,研究人員對(duì)多年來(lái)有關(guān)金黃色葡萄球菌感染的文獻(xiàn)進(jìn)行了研究,結(jié)果發(fā)現(xiàn)在全球大部分地區(qū),,氣溫較高的兩個(gè)季度里都是金黃色葡萄球菌感染的高發(fā)季節(jié),,在熱帶地區(qū)溫度較高的幾個(gè)月里也有類(lèi)似的情況發(fā)生。
麥摩爾表示,,他們查閱了與研究相關(guān)的十年來(lái)羅得島州的氣象資料,,發(fā)現(xiàn)第二季度的平均溫度要高于第四季度。這種滯后或許與金黃色葡萄球菌繁殖相關(guān),。麥摩爾同時(shí)也是美國(guó)布朗大學(xué)沃淪阿爾坡特醫(yī)學(xué)院的醫(yī)學(xué)教授,。
研究人員稱(chēng),研究發(fā)現(xiàn)皮膚中的水合物對(duì)微生物的生長(zhǎng)極為重要,,而只有當(dāng)高溫,、高濕同時(shí)出現(xiàn)時(shí)水合物才會(huì)達(dá)到最大值。因此,,人體皮膚的溫度和濕度可能是影響金黃色葡萄球菌生長(zhǎng)繁殖的最重要的兩個(gè)因素,。
麥摩爾說(shuō):“我們已經(jīng)證明,金黃色葡萄球菌感染,,特別是其對(duì)兒童皮膚的感染有著顯著的季節(jié)模式,。但到目前為止,在不少醫(yī)學(xué)文獻(xiàn)中,,這種人體常見(jiàn)病毒的感染模式卻被普遍忽視,。我們希望這項(xiàng)研究能夠推動(dòng)人們對(duì)金黃色葡萄球菌感染機(jī)制認(rèn)識(shí)的進(jìn)一步深入,從而為該病的防治提供更好的理論基礎(chǔ),。”,。(生物谷Bioon.com)
生物谷推薦原文出處:
PLoS ONE 6(3): e17925. doi:10.1371/journal.pone.0017925
Seasonality of MRSA Infections
Leonard A. Mermel1,2*, Jason T. Machan3,4, Stephen Parenteau1
Using MRSA isolates submitted to our hospital microbiology laboratory January 2001–March 2010 and the number of our emergency department (ED) visits, quarterly community-associated (CA) and hospital-associated (HA) MRSA infections were modeled using Poisson regressions. For pediatric patients, approximately 1.85x (95% CI 1.45x–2.36x, adj. p<0.0001) as many CA-MRSA infections per ED visit occurred in the second two quarters as occurred in the first two quarters. For adult patients, 1.14x (95% CI 1.01x–1.29x, adj.p = 0.03) as many infections per ED visit occurred in the second two quarters as in the first two quarters. Approximately 2.94x (95% CI 1.39x–6.21x, adj.p = 0.015) as many HA-MRSA infections per hospital admission occurred in the second two quarters as occurred in the first two quarters for pediatric patients. No seasonal variation was observed among adult HA-MRSA infections per hospital admission. We demonstrated seasonality of MRSA infections and provide a summary table of similar observations in other studies.