近日,，來自喬治亞州立大學(xué)的研究者通過研究發(fā)現(xiàn),，腸道中正常生存的細(xì)菌和免疫系統(tǒng)之間的“戰(zhàn)斗”，如果被另外一種細(xì)菌所打斷,，可能引發(fā)兩種慢性疾病,。研究中研究者揭示，當(dāng)“煽動(dòng)”細(xì)菌完全被清除掉之后,，這種“戰(zhàn)斗”仍然可以繼續(xù)進(jìn)行,，而且進(jìn)一步會(huì)引發(fā)代謝綜合征或者炎性腸疾病。相關(guān)研究成果刊登在了近日的國(guó)際雜志Cell Host & Microbe上,。
該項(xiàng)研究的結(jié)果對(duì)于理解慢性疾病如代謝綜合征和慢性腸疾病等非常重要,，代謝綜合征包含很多風(fēng)險(xiǎn)因子，包括肥胖等,，而慢性腸疾?。↖BD）包括局限性腸炎和潰瘍性結(jié)腸炎，可引發(fā)痢疾,、出血等,。
據(jù)統(tǒng)計(jì)，每年美國(guó)有超過600,，000人回患上不同類型的炎性腸疾病,。細(xì)菌一般情況下生存于人類腸道之中，細(xì)菌在維持人類健康上扮演著重要作用,，粘膜免疫系統(tǒng)需要很好管理細(xì)菌的環(huán)境來避免炎性疾病的發(fā)生,。（生物谷Bioon.com）
編譯自：Bacteria-Immune System 'Fight' Can Lead to Chronic Diseases, Study Suggests
doi:10.1016/j.chom.2012.07.004
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Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
Frederic A. Carvalho1, 2, 3, Omry Koren4, Julia K. Goodrich4, Malin E.V. Johansson5, Ilke Nalbantoglu6, Jesse D. Aitken1, Yueju Su1, Benoit Chassaing1, William A. Walters7, Antonio González8, Jose C. Clemente9, Tyler C. Cullender4, Nicolas Barnich11, Arlette Darfeuille-Michaud11, Matam Vijay-Kumar1, Rob Knight9, 10, Ruth E. Ley4, Andrew T. Gewirtz1, ,
Colitis results from breakdown of homeostasis between intestinal microbiota and the mucosal immune system, with both environmental and genetic influencing factors. Flagellin receptor TLR5-deficient mice (T5KO) display elevated intestinal proinflammatory gene expression and colitis with incomplete penetrance, providing a genetically sensitized system to study the contribution of microbiota to driving colitis. Both colitic and noncolitic T5KO exhibited transiently unstable microbiotas, with lasting differences in colitic T5KO, while their noncolitic siblings stabilized their microbiotas to resemble wild-type mice. Transient high levels of proteobacteria, especially enterobacteria species including E. coli, observed in close proximity to the gut epithelium were a striking feature of colitic microbiota. A Crohn’s disease-associated E. coli strain induced chronic colitis in T5KO, which persisted well after the exogenously introduced bacterial species had been eliminated. Thus, an innate immune deficiency can result in unstable gut microbiota associated with low-grade inflammation, and harboring proteobacteria can drive and/or instigate chronic colitis.
