[1] Global Concerns Regarding Novel Influenza A (H7N9) Virus Infections
H7N9病毒引發(fā)全球關(guān)注
DOI: 10.1056/NEJMp1304661
Severe disease in humans caused by a novel influenza A virus that is distinct from circulating human influenza A viruses is a seminal event. It might herald sporadic human infections from an animal source — e.g., highly pathogenic avian influenza (HPAI) A (H5N1) virus; or it might signal the start of an influenza pandemic — e.g., influenza A(H1N1)pdm09 virus. Therefore, the discovery of novel influenza A (H7N9) virus infections in three critically ill patients reported in the Journal by Gao and colleagues is of major public health significance. Chinese scientists are to be congratulated for the apparent speed with which the H7N9 virus was identified, and whole viral genome sequences were made publicly available in relatively short order. Because this H7N9 virus has not been detected in humans or animals previously, the situation raises many urgent questions and global public health concerns.
http://www.nejm.org/doi/full/10.1056/NEJMp1304661
[2] H7N9 Incident, immune status, the elderly and a warning of an influenza pandemic
H7N9引發(fā)的死亡事件、其免疫狀態(tài)以及有可能所引發(fā)的一場(chǎng)流感大流行
doi:10.3855/jidc.3675
The novel re-assortment A influenza H7N9 (nrH7N9) emerged in humans in the Shanghai and surrounding provinces of China in late February and early March. Three infected index patients developed severe viral pneumonia with acute respiratory distress syndrome (ARDS) and resulted in fatal outcome. As of 15 April 2013 there were reported 60 confirmed nrH7N9 infections with 13 fatalities. Human-to-human transmission has not been observed, but zoonotic infections of nrH7N9 from birds to humans appear to be associated with live poultry markets. Elderly patients greater than 60 years of age accounted for 61% of the cases, indicating that the elderly may be at high risk for severe disease.
http://www.jidc.org/index.php/journal/article/view/3675
[3] H7N9 avian flu kills seven and infects 23 in China
doi: http://dx.doi.org/10.1136/bmj
http://www.bmj.com/content/346/bmj.f2222?view=long&pmid=23571744