生物谷按：有關(guān)干細(xì)胞的自我更新機(jī)理,，近年來(lái)進(jìn)展十分迅速。三年前大家普遍認(rèn)為是因?yàn)閛ct3/4和LIF信號(hào)通路維持了胚胎干細(xì)胞的自我更新,。去年5月發(fā)現(xiàn)了重要的nanog因子,，去年底進(jìn)一步發(fā)展BMP4-ID信號(hào)通路在防止胚胎干細(xì)胞向外胚胎層（如神經(jīng)）分化中起到關(guān)鍵作用。而國(guó)內(nèi)有實(shí)驗(yàn)室正在篩選與OCT3/4相互作用的因子,，OCTAP（或稱OAP）,，文章也很快發(fā)表。而且去年又成功用胚胎干細(xì)胞誘導(dǎo)出生殖細(xì)胞,。而這篇報(bào)道則是生殖干細(xì)胞自我更新機(jī)理中的重大進(jìn)展,?？梢韵胂螅乱粋€(gè)重要發(fā)現(xiàn)將在成體干細(xì)胞的自我更新機(jī)理,，不同的干細(xì)胞的更新機(jī)理可能有一定差別,。這篇報(bào)道是剛剛出版的science上，是著名的華人學(xué)者林海帆實(shí)驗(yàn)室的成果,，生物谷將關(guān)注干細(xì)胞最新進(jìn)展,。
Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation
Zhong Wang and Haifan Lin*
Despite much progress in understanding how extrinsic signaling regulates stem cell self-renewal, little is known about how cell-autonomous gene regulation controls this process. In Drosophila ovaries, germline stem cells (GSCs) divide asymmetrically to produce daughter GSCs and cystoblasts, the latter of which develop into germline cysts. Here, we show that removing the translational repressor Nanos from either GSCs or their precursors, the primordial germ cells (PGCs), causes both cell types to differentiate into germline cysts. Thus, Nanos is essential for both establishing and maintaining GSCs by preventing their precocious entry into oogenesis. These functions are likely achieved by repressing the translation of differentiation factors in PGCs and GSCs.
Original article:
Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation
Zhong Wang and Haifan Lin
Science 26 March 2004: 2016-2019. Published online 19 February 2004 [DOI:10.1126/science.1093983]
[Full Text] [PDF] [Supporting Online Material]
生物谷內(nèi)相關(guān)報(bào)道：
出生后哺乳動(dòng)物卵巢中的幼稚干細(xì)胞和卵泡能自我更新
胚胎干細(xì)胞能模擬兩性發(fā)育過(guò)程
海螺體內(nèi)發(fā)現(xiàn)阻止人類胚胎干細(xì)胞分化的物質(zhì)
BMP4誘導(dǎo)id蛋白抑制胚胎干細(xì)胞的分化維持自我更新
神經(jīng)干細(xì)胞的自我更新因子Bim-1新研究
干細(xì)胞經(jīng)典文獻(xiàn)下載
