生物谷報(bào)道：復(fù)旦大學(xué)生物醫(yī)學(xué)研究院細(xì)胞分子生物學(xué)研究室管坤良教授和趙世民博士在5月2日出版的Cell發(fā)表了有關(guān)細(xì)胞信號(hào)傳導(dǎo)特異性研究前沿進(jìn)展綜述：Substrate Selectivity APPLies to Akt.
信號(hào)傳導(dǎo)特異性的研究是目前國際信號(hào)傳導(dǎo)研究的熱點(diǎn)之一,。細(xì)胞通過復(fù)雜的信號(hào)“分揀系統(tǒng)”將特定外部刺激產(chǎn)生的信號(hào)準(zhǔn)確地傳達(dá)到細(xì)胞內(nèi)的相關(guān)功能執(zhí)行蛋白,，而且不改變細(xì)胞內(nèi)其它蛋白的功能，進(jìn)而達(dá)到一種外界刺激只引發(fā)特定的生理響應(yīng)（如細(xì)胞的生長、凋亡等）的結(jié)果,。相關(guān)領(lǐng)域的研究突破可能為研制特異的抗癌藥物以及開發(fā)針對其它疾病的特異性藥物帶來新的希望。（生物谷www.bioon.com)
生物谷推薦原始出處：
Cell,，Vol 133, 399-400,，Shimin Zhao，Kun-Liang Guan
Substrate Selectivity APPLies to Akt
Shimin Zhao1 and Kun-Liang Guan2,
1 Laboratory of Molecular and Cellular Biology, Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China
2 Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
Summary
The protein kinase Akt occupies a central position in multiple signaling pathways. Although numerous Akt substrates have been identified, less is known about the factors that regulate specific cellular responses to Akt signaling. In this issue, Schenck et al., 2008 demonstrate that the endosomal protein Appl1 modulates Akt's substrate selectivity to promote cell survival during zebrafish development.
