美國研究人員8月7日宣布,，利用患者體細胞培育出10種可用于觀察遺傳疾病在細胞內發(fā)展的干細胞,。這一進展將有利于尋找這些疾病的治療方法。
哈佛大學干細胞研究所博士喬治·戴利和同事利用患者皮膚細胞和骨髓,，培育出這些干細胞,。這些患者罹患疾病包括帕金森氏癥、亨廷頓舞蹈病和唐氏綜合癥等,。
這種新技術原理是將患者的普通細胞轉化成具有胚胎干細胞特征的干細胞,。胚胎干細胞可分化為不同種類的體細胞，進而成長為人體各種組織,，例如心臟和大腦組織,。這一研究成果發(fā)表在美國《細胞》（Cell）雜志網絡版上。
干細胞研究所所長道格·梅爾頓說,，這些干細胞將有助于研究人員觀察這些疾病在人體細胞內的發(fā)展情況，“我認為,，在數年內我們就會看到這為治療疾病開啟新的大門”,。
梅爾頓說，研究所建立了一所實驗室,，專門儲存這些人造干細胞,，以加速這方面研究。
人體體細胞“轉化”為干細胞曾有先例,。美國和日本研究人員2007年11月報告說,，他們利用重新編排基因技術，把人體皮膚細胞改造成皮膚干細胞,，功能可媲美胚胎干細胞,。上星期，哈佛大學另一研究小組說,，他們把兩名肌肉萎縮性側索硬化癥老年患者的皮膚細胞轉化成干細胞,，再把這些干細胞培育成神經細胞。（生物谷Bioon.com）
生物谷推薦原始出處：
Cell,，In press,，In-Hyun Park, George Q. Daley
Disease-Specific Induced Pluripotent Stem Cells
In-Hyun Park,1,7 Natasha Arora,1,7 Hongguang Huo,1,7 Nimet Maherali,2,3,7 Tim Ahfeldt,2,5,7 Akiko Shimamura,4 M. William Lensch,1,7,9 Chad Cowan,2,6,7 Konrad Hochedlinger,2,7 and George Q. Daley1,7,8,9,
1 Department of Medicine, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, MA 02115
2 Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine and Department of Stem Cell and Regenerative Biology, 185 Cambridge Street, Boston, MA 02114, USA
3 Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
4 Department of Pediatrics, Division of Hematology/Oncology, University of Washington and Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, WA 98109, USA
5 Department of Biochemistry and Molecular Biology II: Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
6 Stowers Medical Institute, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, MA 02115
7 Harvard Stem Cell Institute, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, MA 02115
8 Division of Hematology, Brigham and Women's Hospital, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, MA 02115
9 Howard Hughes Medical Institute, Children's Hospital Boston, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, MA 02115
Corresponding author
George Q. Daley
[email protected]
