美國研究人員8月7日宣布,，利用患者體細(xì)胞培育出10種可用于觀察遺傳疾病在細(xì)胞內(nèi)發(fā)展的干細(xì)胞,。這一進(jìn)展將有利于尋找這些疾病的治療方法。
哈佛大學(xué)干細(xì)胞研究所博士喬治·戴利和同事利用患者皮膚細(xì)胞和骨髓,，培育出這些干細(xì)胞,。這些患者罹患疾病包括帕金森氏癥、亨廷頓舞蹈病和唐氏綜合癥等,。
這種新技術(shù)原理是將患者的普通細(xì)胞轉(zhuǎn)化成具有胚胎干細(xì)胞特征的干細(xì)胞,。胚胎干細(xì)胞可分化為不同種類的體細(xì)胞，進(jìn)而成長為人體各種組織,，例如心臟和大腦組織,。這一研究成果發(fā)表在美國《細(xì)胞》（Cell）雜志網(wǎng)絡(luò)版上。
干細(xì)胞研究所所長道格·梅爾頓說,，這些干細(xì)胞將有助于研究人員觀察這些疾病在人體細(xì)胞內(nèi)的發(fā)展情況,，“我認(rèn)為，在數(shù)年內(nèi)我們就會(huì)看到這為治療疾病開啟新的大門”,。
梅爾頓說,，研究所建立了一所實(shí)驗(yàn)室，專門儲存這些人造干細(xì)胞，以加速這方面研究,。
人體體細(xì)胞“轉(zhuǎn)化”為干細(xì)胞曾有先例,。美國和日本研究人員2007年11月報(bào)告說，他們利用重新編排基因技術(shù),，把人體皮膚細(xì)胞改造成皮膚干細(xì)胞,，功能可媲美胚胎干細(xì)胞。上星期,，哈佛大學(xué)另一研究小組說,，他們把兩名肌肉萎縮性側(cè)索硬化癥老年患者的皮膚細(xì)胞轉(zhuǎn)化成干細(xì)胞，再把這些干細(xì)胞培育成神經(jīng)細(xì)胞,。（生物谷Bioon.com）
生物谷推薦原始出處：
Cell,，In press，In-Hyun Park, George Q. Daley
Disease-Specific Induced Pluripotent Stem Cells
In-Hyun Park,1,7 Natasha Arora,1,7 Hongguang Huo,1,7 Nimet Maherali,2,3,7 Tim Ahfeldt,2,5,7 Akiko Shimamura,4 M. William Lensch,1,7,9 Chad Cowan,2,6,7 Konrad Hochedlinger,2,7 and George Q. Daley1,7,8,9,
1 Department of Medicine, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, MA 02115
2 Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine and Department of Stem Cell and Regenerative Biology, 185 Cambridge Street, Boston, MA 02114, USA
3 Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
4 Department of Pediatrics, Division of Hematology/Oncology, University of Washington and Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, WA 98109, USA
5 Department of Biochemistry and Molecular Biology II: Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
6 Stowers Medical Institute, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, MA 02115
7 Harvard Stem Cell Institute, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, MA 02115
8 Division of Hematology, Brigham and Women's Hospital, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, MA 02115
9 Howard Hughes Medical Institute, Children's Hospital Boston, Karp Family Research Building 7214, 300 Longwood Avenue, Boston, MA 02115
Corresponding author
George Q. Daley
[email protected]
