研究人員近日宣稱,，他們已經(jīng)確定了一些影響人體對(duì)輻射做出反應(yīng)的基因，該發(fā)現(xiàn)可能有助于醫(yī)生調(diào)整對(duì)癌癥等疾病的放射療法,，以達(dá)到最好的治療效果,。研究發(fā)表在最新一期《自然》雜志上。
賓夕法尼亞大學(xué)薇薇安·陳領(lǐng)導(dǎo)了這項(xiàng)研究,，結(jié)果表明,，大約有1200個(gè)基因影響細(xì)胞對(duì)輻射的反應(yīng)，而這些基因都還不為人所知,。
研究團(tuán)隊(duì)使用了30個(gè)毫無關(guān)系的人捐贈(zèng)的細(xì)胞進(jìn)行了研究,，并且用銫放射線對(duì)這些細(xì)胞進(jìn)行了照射。研究結(jié)果表明,，每個(gè)基因?qū)椛涞姆磻?yīng)都不一樣,。有些DNA的表達(dá)或活動(dòng)會(huì)增加，有些會(huì)減少,，還有一些控制其他基因活動(dòng)的轉(zhuǎn)錄因子對(duì)輻射也有影響，也有一些基因同輻射反應(yīng)沒有聯(lián)系,。她表示,，該研究能夠確定輻射對(duì)人們的負(fù)面影響，以供醫(yī)生參考,。
研究指出,，這些結(jié)果對(duì)理解人體細(xì)胞如何對(duì)輻射做出反應(yīng)具有重要意義。醫(yī)生可以使用這些信息來保護(hù)病人,，而且,，這些信息也有助于研發(fā)新藥來提高放療效果。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature advance online publication 6 April 2009 | doi:10.1038/nature07940
Genetic analysis of radiation-induced changes in human gene expression
Denis A. Smirnov1, Michael Morley2, Eunice Shin2, Richard S. Spielman3 & Vivian G. Cheung1,2,3,4
1 Howard Hughes Medical Institute,
2 The Children's Hospital of Philadelphia,
3 Department of Genetics and,
4 Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Humans are exposed to radiation through the environment and in medical settings. To deal with radiation-induced damage, cells mount complex responses that rely on changes in gene expression. These gene expression responses differ greatly between individuals1 and contribute to individual differences in response to radiation2. Here we identify regulators that influence expression levels of radiation-responsive genes. We treated radiation-induced changes in gene expression as quantitative phenotypes3, 4, and conducted genetic linkage and association studies to map their regulators. For more than 1,200 of these phenotypes there was significant evidence of linkage to specific chromosomal regions. Nearly all of the regulators act in trans to influence the expression of their target genes; there are very few cis-acting regulators. Some of the trans-acting regulators are transcription factors, but others are genes that were not known to have a regulatory function in radiation response. These results have implications for our basic and clinical understanding of how human cells respond to radiation.
