近日,，在“發(fā)育與生殖研究”領(lǐng)域國(guó)家重大科學(xué)研究計(jì)劃、國(guó)家自然科學(xué)基金重大研究計(jì)劃和重慶市科委的資助下,，西南大學(xué)教授羅凌飛在細(xì)胞周期與胚胎式建成的偶聯(lián)協(xié)調(diào)機(jī)構(gòu)研究方面取得了新的進(jìn)展,，相關(guān)研究發(fā)表在最近一期的《細(xì)胞生物學(xué)雜志》（The Journal of Cell Biology，2004年至2008年平均影響因子為10.052）上,。
在胚胎的發(fā)育過(guò)程中,，有兩個(gè)方面至關(guān)重要。一方面是細(xì)胞分裂/細(xì)胞周期,，通過(guò)無(wú)數(shù)次的細(xì)胞分裂,，胚胎發(fā)育從一個(gè)單細(xì)胞受精卵發(fā)育為多細(xì)胞成體。另一方面是細(xì)胞分化和模式建成,，通過(guò)細(xì)胞分化和模式建成才能使得多種不同形態(tài)和功能的組織器官出現(xiàn),。這兩個(gè)方面在胚胎發(fā)育過(guò)程中是相互對(duì)話、相互偶聯(lián)并嚴(yán)格協(xié)調(diào)的,。
迄今為止，盡管在細(xì)胞周期和模式建成過(guò)程中的許多重要調(diào)控因子已被發(fā)現(xiàn)，其功能也得到了深入研究,，但對(duì)胚胎發(fā)育中的這兩個(gè)方面如何相互對(duì)話,、相互偶聯(lián)協(xié)調(diào)的分子機(jī)制卻知之甚少。羅凌飛實(shí)驗(yàn)室以斑馬魚(yú)為模式動(dòng)物,，經(jīng)過(guò)近三年的研究,，發(fā)現(xiàn)了細(xì)胞周期與原腸期胚胎模式建成之間偶聯(lián)協(xié)調(diào)的分子機(jī)制，同時(shí)回答了為什么細(xì)胞凋亡恰好從原腸期開(kāi)始出現(xiàn)的問(wèn)題,。（生物谷Bioon.com）
生物谷推薦原始出處：
The Journal of Cell Biology, Vol. 184, No. 6, 805-815 doi:10.1083/jcb.200806074
NF-κB and Snail1a coordinate the cell cycle with gastrulation
Xiaolin Liu1,2, Sizhou Huang1,2, Jun Ma1,2, Chun Li1,2, Yaoguang Zhang1, and Lingfei Luo1,2
1 Key Laboratory of Aquatic Organism Reproduction and Development, Ministry of Education, Key Laboratory of Aquatic Science of Chongqing, and 2 Laboratory of Molecular Developmental Biology, School of Life Science, Southwest University, Beibei, 400715 Chongqing, China
The cell cycle needs to strictly coordinate with developmental processes to ensure correct generation of the body plan and different tissues. However, the molecular mechanism underlying the coordination remains largely unknown. In this study, we investigate how the cell cycle coordinates gastrulation cell movements in zebrafish. We present a system to modulate the cell cycle in early zebrafish embryos by manipulating the geminin-Cdt1 balance. Alterations of the cell cycle change the apoptotic level during gastrulation, which correlates with the nuclear level of antiapoptotic nuclear factor κB (NF-κB). NF-κB associates with the Snail1a promoter region on the chromatin and directly activates Snail1a, an important factor controlling cell delamination, which is the initial step of mesendodermal cell movements during gastrulation. In effect, the cell cycle coordinates the delamination of mesendodermal cells through the transcription of Snail1a. Our results suggest a molecular mechanism by which NF-B and Snail1a coordinate the cell cycle through gastrulation.
