日本研究人員24日說,，體毛根部的毛根細(xì)胞能用來測(cè)定人體生物鐘正常與否,，他們已經(jīng)開發(fā)出了相關(guān)技術(shù),，可幫助預(yù)防或治療抑郁癥,、高血壓和睡眠障礙等與人體生物鐘紊亂有關(guān)的疾病,。
日本山口大學(xué)和佐賀大學(xué)的聯(lián)合研究小組在24日出版的美國(guó)《國(guó)家科學(xué)院學(xué)報(bào)》上發(fā)表論文說,，與血液和口腔內(nèi)黏膜細(xì)胞相比，毛根細(xì)胞含有更豐富的信使核糖核酸（mRNA）,，更加適合用于判斷人體生物鐘狀況,。
研究小組已開發(fā)出相關(guān)檢測(cè)技術(shù)，并在6名男性工人身上進(jìn)行了試驗(yàn),。這6名工人每周輪換一次白班和夜班,。他們說，雖然6人起床時(shí)間約有7小時(shí)的差別,，但體內(nèi)生物鐘卻只錯(cuò)開2小時(shí)左右,，出現(xiàn)了5小時(shí)左右的生物鐘紊亂狀態(tài),。生活節(jié)奏的急劇變化導(dǎo)致體內(nèi)生物鐘無法適應(yīng)，出現(xiàn)慢性生物鐘紊亂,。
參與研究的佐賀大學(xué)醫(yī)學(xué)部教授野出孝一說：“這一技術(shù)有望幫助制定能夠避免出現(xiàn)生物鐘紊亂的值班表,，并決定治療藥物投放的時(shí)間段，以取得最好效果,。”（生物谷Bioon.com）
生物谷推薦原文出處：
PNAS doi:10.1073/pnas.1003878107
Noninvasive method for assessing the human circadian clock using hair follicle cells
Makoto Akashi a , 1 , Haruhiko Soma b , Takuro Yamamoto b , Asuka Tsugitomi c , Shiko Yamashita b , Takuya Yamamoto d , Eisuke Nishida d , Akio Yasuda b , James K. Liao e , and Koichi Node c
A thorough understanding of the circadian clock requires qualitative evaluation of circadian clock gene expression. Thus far, no simple and effective method for detecting human clock gene expression has become available. This limitation has greatly hampered our understanding of human circadian rhythm. Here we report a convenient, reliable, and less invasive method for detecting human clock gene expression using biopsy samples of hair follicle cells from the head or chin. We show that the circadian phase of clock gene expression in hair follicle cells accurately reflects that of individual behavioral rhythms, demonstrating that this strategy is appropriate for evaluating the human peripheral circadian clock. Furthermore, using this method, we indicate that rotating shift workers suffer from a serious time lag between circadian gene expression rhythms and lifestyle. Qualitative evaluation of clock gene expression in hair follicle cells, therefore, may be an effective approach for studying the human circadian clock in the clinical setting.
