成膠質(zhì)細胞瘤是惡性腦癌,，由一個大范圍的血管網(wǎng)絡提供營養(yǎng)。現(xiàn)在,，兩個小組發(fā)現(xiàn),，成膠質(zhì)細胞瘤細胞可以分化成作為腫瘤血管構(gòu)成部分的功能性內(nèi)皮細胞。這些內(nèi)皮細胞以與成膠質(zhì)細胞瘤細胞有同樣基因改變?yōu)樘卣?，并且好像是?ldquo;成膠質(zhì)細胞瘤干樣細胞”形成的,。這項工作表明一些假設的癌癥干細胞可以直接和間接促進癌癥生長，并且還可解釋為什么某些抗血管生成類抗癌藥物沒有療效,，同時也可幫助設計新療法,。（生物谷Bioon.com）
生物谷推薦原文出處：
Nature doi:10.1038/nature09557
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
Lucia Ricci-Vitiani,Roberto Pallini,Mauro Biffoni,Matilde Todaro,Gloria Invernici,Tonia Cenci,Giulio Maira,Eugenio Agostino Parati,Giorgio Stassi,Luigi Maria Larocca& Ruggero De Maria
Glioblastoma is a highly angiogenetic malignancy, the neoformed vessels of which are thought to arise by sprouting of pre-existing brain capillaries. The recent demonstration that a population of glioblastoma stem-like cells (GSCs) maintains glioblastomas1, 2 indicates that the progeny of these cells may not be confined to the neural lineage3. Normal neural stem cells are able to differentiate into functional endothelial cells4. The connection between neural stem cells and the endothelial compartment seems to be critical in glioblastoma, where cancer stem cells closely interact with the vascular niche and promote angiogenesis through the release of vascular endothelial growth factor (VEGF) and stromal-derived factor 1 (refs 5–9). Here we show that a variable number (range 20–90%, mean 60.7%) of endothelial cells in glioblastoma carry the same genomic alteration as tumour cells, indicating that a significant portion of the vascular endothelium has a neoplastic origin. The vascular endothelium contained a subset of tumorigenic cells that produced highly vascularized anaplastic tumours with areas of vasculogenic mimicry in immunocompromised mice. In vitro culture of GSCs in endothelial conditions generated progeny with phenotypic and functional features of endothelial cells. Likewise, orthotopic or subcutaneous injection of GSCs in immunocompromised mice produced tumour xenografts, the vessels of which were primarily composed of human endothelial cells. Selective targeting of endothelial cells generated by GSCs in mouse xenografts resulted in tumour reduction and degeneration, indicating the functional relevance of the GSC-derived endothelial vessels. These findings describe a new mechanism for tumour vasculogenesis and may explain the presence of cancer-derived endothelial-like cells in several malignancies.
